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Research ArticleExperimental Studies

The Effects of Curcumin-based Compounds on Proliferation and Cell Death in Cervical Cancer Cells

XIAOJIE ZHANG, RUBING WANG, GUANGLIN CHEN, LAURENT DEJEAN and QIAO-HONG CHEN
Anticancer Research October 2015, 35 (10) 5293-5298;
XIAOJIE ZHANG
Department of Chemistry, California State University, Fresno, CA, U.S.A.
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RUBING WANG
Department of Chemistry, California State University, Fresno, CA, U.S.A.
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GUANGLIN CHEN
Department of Chemistry, California State University, Fresno, CA, U.S.A.
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LAURENT DEJEAN
Department of Chemistry, California State University, Fresno, CA, U.S.A.
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  • For correspondence: qchen@csufresno.edu ldejean@csufresno.edu
QIAO-HONG CHEN
Department of Chemistry, California State University, Fresno, CA, U.S.A.
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  • For correspondence: qchen@csufresno.edu ldejean@csufresno.edu
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Abstract

Aim: To systematically investigate the effects of a class of curcumin-based compounds on cancer cell viability, proliferation, and apoptosis. Materials and Methods: Cytotoxicity and anti-proliferative potency were estimated by the trypan blue exclusion assay and WST-1 cell proliferation assay, respectively. Cell death pathways were discriminated according to plasma membrane integrity and lipid asymmetry cell profiles using a F2N12S and CYTOX AADvanced double staining flow cytometry-based assay. Results: Nine compounds (2-10) exhibit 13- to 58-fold better cytotoxic and anti-proliferative potencies than curcumin towards HeLa cells. In this cervical cancer cell model, dienone and 1-methylpiperidone serve as the favorable central linkers; 5-methylisoxazol-3-yl and 3-methylisoxazol-5-yl act as the optimal terminal aromatic moiety. Finally, the effects of compounds 6 and 10 on HeLa cells' plasma membrane integrity and lipid asymmetry suggest that the early cytotoxic effect of these compounds is due to a stimulation of apoptosis.

  • Curcumin-based compounds
  • cytotoxicity
  • anti-proliferative activity
  • apoptosis
  • cancer
  • Received June 11, 2015.
  • Revision received July 10, 2015.
  • Accepted July 13, 2015.
  • Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 35 (10)
Anticancer Research
Vol. 35, Issue 10
October 2015
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The Effects of Curcumin-based Compounds on Proliferation and Cell Death in Cervical Cancer Cells
XIAOJIE ZHANG, RUBING WANG, GUANGLIN CHEN, LAURENT DEJEAN, QIAO-HONG CHEN
Anticancer Research Oct 2015, 35 (10) 5293-5298;

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The Effects of Curcumin-based Compounds on Proliferation and Cell Death in Cervical Cancer Cells
XIAOJIE ZHANG, RUBING WANG, GUANGLIN CHEN, LAURENT DEJEAN, QIAO-HONG CHEN
Anticancer Research Oct 2015, 35 (10) 5293-5298;
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Keywords

  • Curcumin-based compounds
  • cytotoxicity
  • anti-proliferative activity
  • apoptosis
  • cancer
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