Molecular Diagnostics and Treatment of Pancreatic Cancer. Systems and Network Biology Approaches

Molecular Diagnostics and Treatment of Pancreatic Cancer. Systems and Network Biology Approaches. Edited by Asfar Azmi. 2014, pp. 446, Eur 71.95, ISBN: 978-0-12-408103-1. Academic Press / Elsevier, London, UK.

This volume describes the different emerging applications of systems biology that are shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems, and addresses new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented along with the attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance.

Additionally, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to microRNAs targetome and dedicates chapters to critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. This work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design.