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Research ArticleExperimental Studies

Combination Immunotherapy with 4-1BB Activation and PD-1 Blockade Enhances Antitumor Efficacy in a Mouse Model of Subcutaneous Tumor

YOSHITARO SHINDO, KIYOSHI YOSHIMURA, ATSUO KURAMASU, YUSAKU WATANABE, HIDEAKI ITO, TOMOKO KONDO, ATSUNORI OGA, HIROSHI ITO, SHIGEFUMI YOSHINO, SHOICHI HAZAMA, KOJI TAMADA, HIDEO YAGITA and MASAAKI OKA
Anticancer Research January 2015, 35 (1) 129-136;
YOSHITARO SHINDO
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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KIYOSHI YOSHIMURA
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
5Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center in Tsukiji, National Cancer Center, Chuo-ku, Tokyo, Japan
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  • For correspondence: kyoshim6705{at}gmail.com
ATSUO KURAMASU
2Department of Molecular Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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YUSAKU WATANABE
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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HIDEAKI ITO
3Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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TOMOKO KONDO
3Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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ATSUNORI OGA
3Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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HIROSHI ITO
3Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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SHIGEFUMI YOSHINO
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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SHOICHI HAZAMA
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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KOJI TAMADA
4Department of Immunology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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HIDEO YAGITA
6Department of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
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MASAAKI OKA
1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
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Article Information

vol. 35 no. 1 129-136
PMID 
25550543

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received August 22, 2014
  • Revision received October 2, 2014
  • Accepted October 8, 2014
  • Published online December 30, 2014.

Copyright & Usage 
Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

Author Information

  1. YOSHITARO SHINDO1,
  2. KIYOSHI YOSHIMURA1,5⇑,
  3. ATSUO KURAMASU2,
  4. YUSAKU WATANABE1,
  5. HIDEAKI ITO3,
  6. TOMOKO KONDO3,
  7. ATSUNORI OGA3,
  8. HIROSHI ITO3,
  9. SHIGEFUMI YOSHINO1,
  10. SHOICHI HAZAMA1,
  11. KOJI TAMADA4,
  12. HIDEO YAGITA6 and
  13. MASAAKI OKA1
  1. 1Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  2. 2Department of Molecular Pharmacology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  3. 3Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  4. 4Department of Immunology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  5. 5Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center in Tsukiji, National Cancer Center, Chuo-ku, Tokyo, Japan
  6. 6Department of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
  1. Correspondence to: Kiyoshi Yoshimura, MD, Ph.D., Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Ube, Yamaguchi 755-8505, Japan. Tel: +81 836222264, Fax: +81 836222263, e-mail: kyoshim6705{at}gmail.com
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Combination Immunotherapy with 4-1BB Activation and PD-1 Blockade Enhances Antitumor Efficacy in a Mouse Model of Subcutaneous Tumor
YOSHITARO SHINDO, KIYOSHI YOSHIMURA, ATSUO KURAMASU, YUSAKU WATANABE, HIDEAKI ITO, TOMOKO KONDO, ATSUNORI OGA, HIROSHI ITO, SHIGEFUMI YOSHINO, SHOICHI HAZAMA, KOJI TAMADA, HIDEO YAGITA, MASAAKI OKA
Anticancer Research Jan 2015, 35 (1) 129-136;

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Combination Immunotherapy with 4-1BB Activation and PD-1 Blockade Enhances Antitumor Efficacy in a Mouse Model of Subcutaneous Tumor
YOSHITARO SHINDO, KIYOSHI YOSHIMURA, ATSUO KURAMASU, YUSAKU WATANABE, HIDEAKI ITO, TOMOKO KONDO, ATSUNORI OGA, HIROSHI ITO, SHIGEFUMI YOSHINO, SHOICHI HAZAMA, KOJI TAMADA, HIDEO YAGITA, MASAAKI OKA
Anticancer Research Jan 2015, 35 (1) 129-136;
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Keywords

  • cancer immunotherapy
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