Optimization in Drug Discovery

Optimization in Drug Discovery. Edited by G.W. Caldwell, Z. Yan. 2014, pp. 597, Eur 133.74, ISBN: 978-1-62703-741-9. Springer Science + Business Media, New York, NY, USA.

This revised second edition of Optimization in Drug Discovery: In Vitro Methods presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. This book aims to guide researchers down the difficult path to successful drug discovery and development.