This book describes the benefits of Structural Genomics to the wider structural research community. Structural Genomics: General Applications helps the researcher understand macromolecular machineries and complexes. Divided into three convenient sections, topics include the cloning and production of proteins for structural studies, experimental methods, and computational methods and data analysis. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. This book aims primarily to channel spin-off technologies to the average structural biologist in a small or medium-sized laboratory.
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