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Research ArticleClinical Studies

Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer

STEFAN HOLDENRIEDER, YOGANIRANJANA DHARUMAN, JENS STANDOP, NICOLAI TRIMPOP, MARIELLE HERZOG, KARINA HETTWER, KIRSTEN SIMON, STEFFEN UHLIG and JAKE MICALLEF
Anticancer Research May 2014, 34 (5) 2357-2362;
STEFAN HOLDENRIEDER
1Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany
5Joint Research and Services Center for Biomarker Evaluation in Oncology, Germany
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  • For correspondence: Stefan.Holdenrieder@uni-bonn.de
YOGANIRANJANA DHARUMAN
1Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany
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JENS STANDOP
2Department of Surgery, University Hospital Bonn, Bonn, Germany
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NICOLAI TRIMPOP
1Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany
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MARIELLE HERZOG
3Belgian Volition SA, Namur, Belgium
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KARINA HETTWER
4QuoData Statistics, Dresden, Germany
5Joint Research and Services Center for Biomarker Evaluation in Oncology, Germany
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KIRSTEN SIMON
4QuoData Statistics, Dresden, Germany
5Joint Research and Services Center for Biomarker Evaluation in Oncology, Germany
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STEFFEN UHLIG
4QuoData Statistics, Dresden, Germany
5Joint Research and Services Center for Biomarker Evaluation in Oncology, Germany
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JAKE MICALLEF
3Belgian Volition SA, Namur, Belgium
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    Figure 1.

    Distribution of serum levels of 5-methylated cytosines (NuQ-X), indicating means (rhombes), medians (lines), interquartile (boxes), 1.5-times interquartile ranges (whiskers), outliers (circles), and extreme values (crosses) in healthy controls (HC), patients with benign colorectal diseases (BCD) and patients with colorectal cancer (CRC) in the first (a) and second (b) set of patients.

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    Figure 2.

    Receiver operating characteristic curves of 5-methylated cytosine (NuQ-X) for the differentiation of patients with colorectal cancer from healthy controls in the first (a) and second (b) set of patients.

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Anticancer Research: 34 (5)
Anticancer Research
Vol. 34, Issue 5
May 2014
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Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer
STEFAN HOLDENRIEDER, YOGANIRANJANA DHARUMAN, JENS STANDOP, NICOLAI TRIMPOP, MARIELLE HERZOG, KARINA HETTWER, KIRSTEN SIMON, STEFFEN UHLIG, JAKE MICALLEF
Anticancer Research May 2014, 34 (5) 2357-2362;

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Novel Serum Nucleosomics Biomarkers for the Detection of Colorectal Cancer
STEFAN HOLDENRIEDER, YOGANIRANJANA DHARUMAN, JENS STANDOP, NICOLAI TRIMPOP, MARIELLE HERZOG, KARINA HETTWER, KIRSTEN SIMON, STEFFEN UHLIG, JAKE MICALLEF
Anticancer Research May 2014, 34 (5) 2357-2362;
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Keywords

  • Colorectal cancer
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