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Research ArticleClinical Studies

Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer

SHARIF B. MOHR, EDWARD D. GORHAM, JUNE KIM, HEATHER HOFFLICH and CEDRIC F. GARLAND
Anticancer Research March 2014, 34 (3) 1163-1166;
SHARIF B. MOHR
1Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA, U.S.A.
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  • For correspondence: sbmohr75@gmail.com
EDWARD D. GORHAM
1Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA, U.S.A.
2Department of Family and Preventive Medicine 0620, University of California, San Diego, La Jolla, CA, U.S.A.
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JUNE KIM
1Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA, U.S.A.
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HEATHER HOFFLICH
2Department of Family and Preventive Medicine 0620, University of California, San Diego, La Jolla, CA, U.S.A.
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CEDRIC F. GARLAND
1Scientific Programs Office, Code 01A, Naval Health Research Center, San Diego, CA, U.S.A.
2Department of Family and Preventive Medicine 0620, University of California, San Diego, La Jolla, CA, U.S.A.
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Abstract

Background/Aim: To determine whether higher serum 25-hydroxyvitamin D [25(OH)D] at diagnosis is associated with longer survival of patients with breast cancer. Materials and Methods: A meta-analysis was performed of five studies of the relationship between 25(OH)D and mortality from breast cancer. A pooled hazard ratio was calculated using a random-effects model. The Der Simonian-Laird test was used to assess homogeneity. Results: Higher serum concentrations of 25(OH)D were associated with lower case-fatality rates after diagnosis of breast cancer. Specifically, patients in the highest quintile of 25(OH)D had approximately half the death rate from breast cancer as those in the lowest. Conclusion: High serum 25(OH)D was associated with lower mortality from breast cancer. Serum 25(OH)D in all patients with breast cancer should be restored to the normal range (30-80 ng/ml), with appropriate monitoring. Clinical or field studies should be initiated to confirm that this association was not due to reverse causation.

  • Breast cancer
  • vitamin D
  • epidemiology
  • survival
  • mortality
  • meta-analysis
  • Received December 15, 2013.
  • Revision received January 7, 2014.
  • Accepted January 9, 2014.
  • Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 34 (3)
Anticancer Research
Vol. 34, Issue 3
March 2014
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Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer
SHARIF B. MOHR, EDWARD D. GORHAM, JUNE KIM, HEATHER HOFFLICH, CEDRIC F. GARLAND
Anticancer Research Mar 2014, 34 (3) 1163-1166;

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Meta-analysis of Vitamin D Sufficiency for Improving Survival of Patients with Breast Cancer
SHARIF B. MOHR, EDWARD D. GORHAM, JUNE KIM, HEATHER HOFFLICH, CEDRIC F. GARLAND
Anticancer Research Mar 2014, 34 (3) 1163-1166;
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Keywords

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