Research ArticleClinical Studies

Baseline Central Nervous System Magnetic Resonance Imaging in Early Detection of Trilateral Retinoblastoma: Pitfalls in the Diagnosis of Pineal Gland Lesions

MARIA ANTONIETTA DE IORIS, PAOLA VALENTE, FRANCESCO RANDISI, LUCA BUZZONETTI, ANDREA CARAI, RAFFAELE COZZA, FRANCESCA DEL BUFALO, ANTONINO ROMANZO, ADRIANO ANGIONI, ANTONELLA CACCHIONE, BRUNO BERNARDI and ANGELA MASTRONUZZI
Anticancer Research December 2014, 34 (12) 7449-7454;

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Patient 1. Axial T1-weighted images (T1WI) (a) show the enucleated left eye and a small in the right eye (arrow). Axial TSE T2WI (b), axial and sagittal T1WI (c, d) reveal a well-circumscribed pineal mass, with a maximum diameter of 15 mm. Sagittal (e) and axial (f) SE T1W images with contrast show a homogenously enhancing pineal mass.

  • Figure 2.
    Figure 2.

    Patient 2 (first magnetic resonance imaging). Axial T2WI t (a) shows a bilateral. Sagittal SE T1WI (b) presents a 7-mm solid pineal gland with low apparent diffusion coefficient (ADC) value (c). The pineal gland shows and intense and homogeneous contrast enhancement (d).

  • Figure 3.
    Figure 3.

    Patient 2 (second magnetic resonance imaging after six months). Axial TSE T2WI (a) shows a marked reduction in the size of the ocular mass, bilaterally. Sagittal SE T1WI (b) demonstrates the initial cystic evolution of the pineal gland mass, presenting a more heterogeneous signal, confirmed by the higher ADC values compared to the previous study (c). The sagittal T1W post-contrast image (d) reveals the presence of an irregular enhancing ring wall with tiny nodules (arrow).

  • Figure 4.
    Figure 4.

    Patient 2 (third magnetic resonance imaging after 12 months). Sagittal (a) T1WI shows the cystic progression of the lesion, confirmed by (b) sagittal (arrow) and axial (c) contrast-enhanced images and by an increase of the value (d). Mild collapse of the gland is apparent, showing an enhancing wall more regular and thinner than before.

  • Figure 5.
    Figure 5.

    Patient 3. Axial T2WI (a) shows a bilateral. Sagittal SE T1W1 (b) shows a 7-8 mm pineal lesion with an anterior small cystic component (arrow). The solid part of the lesion enhances after contrast medium (d) and presents a low ADC (c).

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Baseline Central Nervous System Magnetic Resonance Imaging in Early Detection of Trilateral Retinoblastoma: Pitfalls in the Diagnosis of Pineal Gland Lesions
MARIA ANTONIETTA DE IORIS, PAOLA VALENTE, FRANCESCO RANDISI, LUCA BUZZONETTI, ANDREA CARAI, RAFFAELE COZZA, FRANCESCA DEL BUFALO, ANTONINO ROMANZO, ADRIANO ANGIONI, ANTONELLA CACCHIONE, BRUNO BERNARDI, ANGELA MASTRONUZZI
Anticancer Research Dec 2014, 34 (12) 7449-7454;
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