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Research ArticleClinical Studies

Role of Interferon-alpha in Patients with Neuroendocrine Tumors: A Retrospective Study

EITAN MIRVIS, DALVINDER MANDAIR, JORGE GARCIA-HERNANDEZ, MULLAN MOHMADUVESH, CHRISTOS TOUMPANAKIS and MARTYN CAPLIN
Anticancer Research November 2014, 34 (11) 6601-6607;
EITAN MIRVIS
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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DALVINDER MANDAIR
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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JORGE GARCIA-HERNANDEZ
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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MULLAN MOHMADUVESH
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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CHRISTOS TOUMPANAKIS
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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MARTYN CAPLIN
Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, U.K.
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  • For correspondence: m.caplin{at}ucl.ac.uk
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    Figure 1.

    Radiological response to interferon-alpha (IFNα) at each time point. Overall, 71% of patients had at least 3 months of stable disease (SD) or partial response (PR). CR: Complete response; PD: progressive disease.

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    Figure 2.

    Kaplan–Meier plot of progression-free survival (PFS) for patients on interferon-alpha (IFNα) monotherapy or with a stable dose of somatostatin analogue prior to IFNα therapy, for all tumor types (N=16), and midgut (N=9) and pancreatic (N=5) tumours. The survival of patients in the midgut and pancreatic subgroups were not significantly different (p=0.657, log-rank test).

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    Figure 3.

    Toxicities to interferon-alpha graded according to the Common Terminology Criteria for Adverse Events Version 4.0. Grade 1: Mild; grade 2: moderate; grade 3: severe; grade 4: life-threatening. There were no grade 4 toxicities.

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Anticancer Research
Vol. 34, Issue 11
November 2014
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Role of Interferon-alpha in Patients with Neuroendocrine Tumors: A Retrospective Study
EITAN MIRVIS, DALVINDER MANDAIR, JORGE GARCIA-HERNANDEZ, MULLAN MOHMADUVESH, CHRISTOS TOUMPANAKIS, MARTYN CAPLIN
Anticancer Research Nov 2014, 34 (11) 6601-6607;

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Role of Interferon-alpha in Patients with Neuroendocrine Tumors: A Retrospective Study
EITAN MIRVIS, DALVINDER MANDAIR, JORGE GARCIA-HERNANDEZ, MULLAN MOHMADUVESH, CHRISTOS TOUMPANAKIS, MARTYN CAPLIN
Anticancer Research Nov 2014, 34 (11) 6601-6607;
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Keywords

  • Interferon-alpha
  • neuroendocrine tumours
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