Resistance to Abiraterone in Castration-resistant Prostate Cancer: A Review of the Literature

Pathway of androgen metabolism. CYP11A1, cytochrome P450, family 11, subfamily A, polypeptide 1; CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1; DHEA, dehydroepiandrosterone; DHT, dihydrotestosterone; 3βHSD, 3β-hydroxysteroid dehydrogenase; SRD5A, 5α-reductase; 17βHSD, 17β-hydroxysteroid dehydrogenase; 3αHSD, 3α-hydroxysteroid dehydrogenase. The canonical pathway is shown in light grey, the 5α-androstenedione pathway in grey, and the ‘backdoor’ pathway in dark grey.