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Research ArticleClinical Studies

Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma

MASAKI IIDA, EIJI TAKAYAMA, KOSUKE NAGANAWA, KENJI MITSUDO, MAKOTO ADACHI, JUN-ICHI BABA, MASAKO FUJIMOTO-MUTO, MASAYUKI MOTOHASHI, MASAKO MIZUNO-KAMIYA, HARUMI KAWAKI, MITOMU KIOI, MASAO ICHINOSE, SHIN-ICHIRO SUMITOMO, YASUNORI MURAMATSU, MICHIO SHIKIMORI, IWAI TOHNAI and NOBUO KONDOH
Anticancer Research October 2014, 34 (10) 5729-5734;
MASAKI IIDA
1Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
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EIJI TAKAYAMA
2Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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KOSUKE NAGANAWA
2Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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KENJI MITSUDO
1Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
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MAKOTO ADACHI
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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JUN-ICHI BABA
1Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
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MASAKO FUJIMOTO-MUTO
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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MASAYUKI MOTOHASHI
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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MASAKO MIZUNO-KAMIYA
2Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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HARUMI KAWAKI
2Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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MITOMU KIOI
1Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
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MASAO ICHINOSE
4Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
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SHIN-ICHIRO SUMITOMO
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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YASUNORI MURAMATSU
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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MICHIO SHIKIMORI
3Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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IWAI TOHNAI
1Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan
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NOBUO KONDOH
2Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan
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  • For correspondence: nkondoh{at}dent.asahi-u.ac.jp
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    Figure 1.

    Analysis of cluster of differentiation (CD) 57+ T-cells in peripheral blood (PB) from patients with oral squamous cell carcinoma by tumor stage. The proportion of total T-cells to PB lymphocytes (PBLs) (A), CD57+ T-cells to PBLs (B), and of CD57+ T-cells to total T-cells (C) are indicated. Data are mean±SD.*p<0.05, **p<0.01.

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    Figure 2.

    Analysis of CD57+ T-cell subsets of CD8+ T-cells from patients by tumor stage. The proportion of CD8+CD57+ T-cells to PBLs (A), to CD8+ T-cells (B), and of CD8+ T-cells to total PBLs (C) are indicated. Data are mean±SD.*p<0.05, **p<0.01.

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    Figure 3.

    Analysis of CD57+ T-cell subsets of CD4+ T-cells from patients by tumor stage. The proportion of CD4+CD57+ T-cells to PBLs (A), to CD4+ T-cells (B), and of CD4+ T-cells to total PBLs (C) are indicated. Data are mean±SD.*p<0.05, **p<0.01.

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    Figure 4.

    Analysis of CD57+ T-cell subsets in patients by tumor sizes according to TNM classification. The proportion of CD57+ T-cells (A), CD8+CD57+ T-cells (B) to PBLs, and CD4+CD57+ T-cells to CD4+ T-cells (C) are indicated. Data are mean±SD.*p<0.05, **p<0.01.

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Anticancer Research
Vol. 34, Issue 10
October 2014
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Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma
MASAKI IIDA, EIJI TAKAYAMA, KOSUKE NAGANAWA, KENJI MITSUDO, MAKOTO ADACHI, JUN-ICHI BABA, MASAKO FUJIMOTO-MUTO, MASAYUKI MOTOHASHI, MASAKO MIZUNO-KAMIYA, HARUMI KAWAKI, MITOMU KIOI, MASAO ICHINOSE, SHIN-ICHIRO SUMITOMO, YASUNORI MURAMATSU, MICHIO SHIKIMORI, IWAI TOHNAI, NOBUO KONDOH
Anticancer Research Oct 2014, 34 (10) 5729-5734;

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Increase of Peripheral Blood CD57+ T-Cells in Patients with Oral Squamous Cell Carcinoma
MASAKI IIDA, EIJI TAKAYAMA, KOSUKE NAGANAWA, KENJI MITSUDO, MAKOTO ADACHI, JUN-ICHI BABA, MASAKO FUJIMOTO-MUTO, MASAYUKI MOTOHASHI, MASAKO MIZUNO-KAMIYA, HARUMI KAWAKI, MITOMU KIOI, MASAO ICHINOSE, SHIN-ICHIRO SUMITOMO, YASUNORI MURAMATSU, MICHIO SHIKIMORI, IWAI TOHNAI, NOBUO KONDOH
Anticancer Research Oct 2014, 34 (10) 5729-5734;
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Keywords

  • Oral squamous cell carcinoma
  • CD57
  • T-cells
  • peripheral blood
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