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Research ArticleExperimental Studies

Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells

XIANG-SHU XIAN, HYEYEON PARK, MYUNG-GYU CHOI and JAE MYUNG PARK
Anticancer Research June 2013, 33 (6) 2541-2547;
XIANG-SHU XIAN
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
2Division of Gastroenterology, Department of Internal Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
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HYEYEON PARK
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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MYUNG-GYU CHOI
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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JAE MYUNG PARK
1Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
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  • For correspondence: parkjerry@catholic.ac.kr
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Abstract

Fluorouracil is the main chemotherapeutic drug used for gastrointestinal cancers, which suffers the important problem of treatment resistance. There is little information whether cannabinoid agonists can be used as an alternative drug for fluorouracil-resistant gastric cancer cells. In this study, we investigated the effects of a cannabinoid agonist, WIN-55,212-2, on 5-fluorouracil (5-FU)-resistant human gastric cancer cells, to examine whether the cannabinoid agonist may be an alternative therapy. Survival of the 5-FU-resistant gastric cancer cell line, SNU-620-5FU/1000, was not significantly reduced even by a high dose of 5-FU treatment. However, WIN-55,212-2 inhibited the proliferation of SNU-620-5FU/1000 and enhanced their apoptosis, as indicated by an increase of apoptotic cell proportion, activated caspase-3 and Poly (ADP-ribose) polymerase cleavage. Furthermore, WIN-55,212-2 reduced phospho-extracellular-signal-regulated kinases (ERK) 1/2, phospho-Akt (protein kinase B), B-cell lymphoma-2 (BCL2) and BCL2-associated X (BAX) protein expression in 5-FU-resistant gastric cancer cells. These results indicate that a cannabinoid agonist may, indeed, be an alternative chemotherapeutic agent for 5-FU-resistant gastric cancer.

  • Gastric cancer
  • cannabinoids
  • fluorouracil
  • drug resistance
  • apoptosis
  • Received March 10, 2013.
  • Revision received April 18, 2013.
  • Accepted April 22, 2013.
  • Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 33 (6)
Anticancer Research
Vol. 33, Issue 6
June 2013
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Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
XIANG-SHU XIAN, HYEYEON PARK, MYUNG-GYU CHOI, JAE MYUNG PARK
Anticancer Research Jun 2013, 33 (6) 2541-2547;

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Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
XIANG-SHU XIAN, HYEYEON PARK, MYUNG-GYU CHOI, JAE MYUNG PARK
Anticancer Research Jun 2013, 33 (6) 2541-2547;
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Keywords

  • gastric cancer
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