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Research ArticleClinical Studies

Missense Polymorphisms in XIAP-Associated Factor-1 (XAF1) and Risk of Papillary Thyroid Cancer: Correlation with Clinicopathological Features

SU KANG KIM, HAE JEONG PARK, HOSIK SEOK, HYE SOOK JEON, JONG WOO KIM, JOO-HO CHUNG, KEE HWAN KWON, SEUNG-HOON WOO, BYOUNG WOOK LEE and HYUNG HWAN BAIK
Anticancer Research May 2013, 33 (5) 2205-2210;
SU KANG KIM
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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HAE JEONG PARK
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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HOSIK SEOK
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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HYE SOOK JEON
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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JONG WOO KIM
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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JOO-HO CHUNG
1Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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KEE HWAN KWON
2Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University College of Medicine, Anyang, Republic of Korea
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SEUNG-HOON WOO
3Department of Anesthesiology, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea
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BYOUNG WOOK LEE
4Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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HYUNG HWAN BAIK
4Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
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  • For correspondence: minju801004@gmail.com
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Abstract

X-Linked inhibitor of apoptosis (XIAP)-associated factor-1 (XAF1) antagonizes XIAP-mediated caspase inhibition. XAF1 also serves as a tumor-suppressor gene, and loss of XAF1 expression correlates with tumor progression. This study investigated whether XAF1 missense single-nucleotide polymorphisms (SNPs) are associated with the development of papillary thyroid cancer (PTC) and their clinicopathological features in a Korean population. Eighty-nine cases of PTC and 276 controls were enrolled. Two missense SNPs [rs34195599 (Glu85Gly) and rs2271232 (Arg132His)] in XAF1 were genotyped using direct sequencing. The SNPStats, SNPAnalyzer, Helixtree, and Haploview version 4.2 programs were used to evaluate genetic data. Multiple logistic regression models were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and p-values. Missense SNP rs34195599 was weakly-associated with the development of PTC (p=0.046 in genotypic distributions; p=0.048 in allelic distributions). For the clinicopathological features, rs34195599 was strongly related to multifocality [unifocality (A/G, 1.7%) vs. multifocality (A/G, 16.7%), OR=11.44, 95% CI=1.27-103.26, p=0.015 in genotypic distributions] [unifocality (G, 0.8%) vs. multifocality (G, 8.3%), OR=10.64, 95% CI=1.21-93.23, p=0.017 in allelic distributions] and location [one lobe (A/G, 1.6%) vs. both lobes (A/G, 19.2%), OR=15.63, 95% CI=1.62-150.46, p=0.008 in genotypic distributions] [one lobe (G, 0.8%) vs. both lobes (G, 9.6%), OR=13.30, 95% CI=1.51-116.82, p=0.009 in allelic distributions]. Our data suggest that the G allele of rs34195599 of XAF1 may be a risk factor for the clinicopathological features of PTC, especially for multifocality and location (both lobes).

  • Clinicopathological features
  • papillary thyroid cancer
  • polymorphism
  • XAF1
  • Received March 21, 2013.
  • Revision received April 16, 2013.
  • Accepted April 17, 2013.
  • Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 33 (5)
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Missense Polymorphisms in XIAP-Associated Factor-1 (XAF1) and Risk of Papillary Thyroid Cancer: Correlation with Clinicopathological Features
SU KANG KIM, HAE JEONG PARK, HOSIK SEOK, HYE SOOK JEON, JONG WOO KIM, JOO-HO CHUNG, KEE HWAN KWON, SEUNG-HOON WOO, BYOUNG WOOK LEE, HYUNG HWAN BAIK
Anticancer Research May 2013, 33 (5) 2205-2210;

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Missense Polymorphisms in XIAP-Associated Factor-1 (XAF1) and Risk of Papillary Thyroid Cancer: Correlation with Clinicopathological Features
SU KANG KIM, HAE JEONG PARK, HOSIK SEOK, HYE SOOK JEON, JONG WOO KIM, JOO-HO CHUNG, KEE HWAN KWON, SEUNG-HOON WOO, BYOUNG WOOK LEE, HYUNG HWAN BAIK
Anticancer Research May 2013, 33 (5) 2205-2210;
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Keywords

  • clinicopathological features
  • papillary thyroid cancer
  • polymorphism
  • XAF1
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