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Research ArticleExperimental Studies

Heterogeneous Sensitivity of Hepatocellular Carcinoma to Sorafenib Revealed by the Short-term Culture of Tumor Fragments

CORINNE GODIN, SEBASTIEN DUPONT, ZAKARIA EZZOUKHRY, CHRISTOPHE LOUANDRE, DENIS CHATELAIN, LUCIE HENAUT, CHARLES SABBAGH, JEAN-MARC REGIMBEAU, JEAN-CLAUDE MAZIERE, JEAN-CLAUDE BARBARE, BRUNO CHAUFFERT and ANTOINE GALMICHE
Anticancer Research April 2013, 33 (4) 1415-1420;
CORINNE GODIN
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
2Department of Biochemistry, CHU Amiens, Amiens, France
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SEBASTIEN DUPONT
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
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ZAKARIA EZZOUKHRY
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
2Department of Biochemistry, CHU Amiens, Amiens, France
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CHRISTOPHE LOUANDRE
2Department of Biochemistry, CHU Amiens, Amiens, France
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DENIS CHATELAIN
3Department of Pathology, CHU Amiens, Amiens, France
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LUCIE HENAUT
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
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CHARLES SABBAGH
4Department of Surgery, CHU Amiens, Amiens, France
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JEAN-MARC REGIMBEAU
4Department of Surgery, CHU Amiens, Amiens, France
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JEAN-CLAUDE MAZIERE
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
2Department of Biochemistry, CHU Amiens, Amiens, France
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JEAN-CLAUDE BARBARE
6Department of Clinical Research and Innovation, CHU Amiens, Amiens, France
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BRUNO CHAUFFERT
5Department of Clinical Oncology, CHU Amiens, Amiens, France
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ANTOINE GALMICHE
1Inserm U1088, University of Picardie Jules Verne, Amiens, France
2Department of Biochemistry, CHU Amiens, Amiens, France
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  • For correspondence: Galmiche.Antoine{at}chu-amiens.fr
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Article Information

vol. 33 no. 4 1415-1420
PMID 
23564781

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received January 7, 2013
  • Revision received March 5, 2013
  • Accepted March 5, 2013
  • Published online April 6, 2013.

Copyright & Usage 
Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

Author Information

  1. CORINNE GODIN1,2,*,
  2. SEBASTIEN DUPONT1,*,
  3. ZAKARIA EZZOUKHRY1,2,*,
  4. CHRISTOPHE LOUANDRE2,
  5. DENIS CHATELAIN3,
  6. LUCIE HENAUT1,
  7. CHARLES SABBAGH4,
  8. JEAN-MARC REGIMBEAU4,
  9. JEAN-CLAUDE MAZIERE1,2,
  10. JEAN-CLAUDE BARBARE6,
  11. BRUNO CHAUFFERT5,# and
  12. ANTOINE GALMICHE1,2,#⇑
  1. 1Inserm U1088, University of Picardie Jules Verne, Amiens, France
  2. 2Department of Biochemistry, CHU Amiens, Amiens, France
  3. 3Department of Pathology, CHU Amiens, Amiens, France
  4. 4Department of Surgery, CHU Amiens, Amiens, France
  5. 5Department of Clinical Oncology, CHU Amiens, Amiens, France
  6. 6Department of Clinical Research and Innovation, CHU Amiens, Amiens, France
  1. Correspondence to: Antoine Galmiche, Centre de Biologie Humaine, CHU Amiens Sud, 80054 Salouel, France. Tel: +33 0322087017, Fax: +33(0)322087026, e-mail: Galmiche.Antoine{at}chu-amiens.fr
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Heterogeneous Sensitivity of Hepatocellular Carcinoma to Sorafenib Revealed by the Short-term Culture of Tumor Fragments
CORINNE GODIN, SEBASTIEN DUPONT, ZAKARIA EZZOUKHRY, CHRISTOPHE LOUANDRE, DENIS CHATELAIN, LUCIE HENAUT, CHARLES SABBAGH, JEAN-MARC REGIMBEAU, JEAN-CLAUDE MAZIERE, JEAN-CLAUDE BARBARE, BRUNO CHAUFFERT, ANTOINE GALMICHE
Anticancer Research Apr 2013, 33 (4) 1415-1420;

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Heterogeneous Sensitivity of Hepatocellular Carcinoma to Sorafenib Revealed by the Short-term Culture of Tumor Fragments
CORINNE GODIN, SEBASTIEN DUPONT, ZAKARIA EZZOUKHRY, CHRISTOPHE LOUANDRE, DENIS CHATELAIN, LUCIE HENAUT, CHARLES SABBAGH, JEAN-MARC REGIMBEAU, JEAN-CLAUDE MAZIERE, JEAN-CLAUDE BARBARE, BRUNO CHAUFFERT, ANTOINE GALMICHE
Anticancer Research Apr 2013, 33 (4) 1415-1420;
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Keywords

  • Hepatocellular carcinoma
  • sorafenib
  • RAF kinases
  • short-term culture
  • tumour fragments
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