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Research ArticleClinical Studies

Progression-free Survival Is Accurately Predicted in Patients Treated with Chemotherapy for Epithelial Ovarian Cancer by the Histoculture Drug Response Assay in a Prospective Correlative Clinical Trial at a Single Institution

PHILL-SEUNG JUNG, DAE-YEON KIM, MOON-BO KIM, SHIN-WHA LEE, JONG-HYEOK KIM, YONG-MAN KIM, YOUNG-TAK KIM, ROBERT M. HOFFMAN and JOO-HYUN NAM
Anticancer Research March 2013, 33 (3) 1029-1034;
PHILL-SEUNG JUNG
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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DAE-YEON KIM
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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  • For correspondence: kdyog@amc.seoul.kr
MOON-BO KIM
2MetaBio Institute, Seoul, Korea
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SHIN-WHA LEE
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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JONG-HYEOK KIM
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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YONG-MAN KIM
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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YOUNG-TAK KIM
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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ROBERT M. HOFFMAN
3AntiCancer, Inc., San Diego, CA, U.S.A.
4Department of Surgery, University of California, San Diego, San Diego, CA, U.S.A.
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JOO-HYUN NAM
1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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    Figure 1.

    Average inhibition rate (IRs) of tumors for drugs in the HDRA for 104 ovarian cancer. BLM: Bleomycin; VP16: etoposide; ADR: adriamycin; TOP: topotecan; GEM: gemcitabine; lFS: ifosphamide; BEL: belotecan; CDDP: cisplatin; DTAX: detaxel; CBP: carboplatin.

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    Figure 2.

    Kaplan–Meier survival curves showing progression-free survival of patients sensitive to both taxol and carboplatin (SS group, n=24), and patients not sensitive to either drug (R group, n=49). The median PFS was longer in the SS group than in the R group (34.0 vs. 16.0 months, p=0.03).

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    Figure 3.

    Kaplan–Meier survival curves showing overall survival of patients sensitive to both taxol and carboplatin (SS group, n=24), and those not sensitive to either drug (R group, n=49) (p=0.27).

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Anticancer Research: 33 (3)
Anticancer Research
Vol. 33, Issue 3
March 2013
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Progression-free Survival Is Accurately Predicted in Patients Treated with Chemotherapy for Epithelial Ovarian Cancer by the Histoculture Drug Response Assay in a Prospective Correlative Clinical Trial at a Single Institution
PHILL-SEUNG JUNG, DAE-YEON KIM, MOON-BO KIM, SHIN-WHA LEE, JONG-HYEOK KIM, YONG-MAN KIM, YOUNG-TAK KIM, ROBERT M. HOFFMAN, JOO-HYUN NAM
Anticancer Research Mar 2013, 33 (3) 1029-1034;

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Progression-free Survival Is Accurately Predicted in Patients Treated with Chemotherapy for Epithelial Ovarian Cancer by the Histoculture Drug Response Assay in a Prospective Correlative Clinical Trial at a Single Institution
PHILL-SEUNG JUNG, DAE-YEON KIM, MOON-BO KIM, SHIN-WHA LEE, JONG-HYEOK KIM, YONG-MAN KIM, YOUNG-TAK KIM, ROBERT M. HOFFMAN, JOO-HYUN NAM
Anticancer Research Mar 2013, 33 (3) 1029-1034;
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Keywords

  • chemosensitivity
  • HDRA
  • histoculture drug response assay
  • epithelial ovarian cancer
  • Taxol
  • Carboplatin
  • prospective clinical trial
  • correlation
  • prediction
  • individualized therapy
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