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Research ArticleExperimental Studies

Chemoprevention of Oral Cancer by Lyophilized Strawberries

BRUCE C. CASTO, THOMAS J. KNOBLOCH, REBECCA L. GALIOTO, ZHANGSHENG YU, BRENT T. ACCURSO and BLAKE M. WARNER
Anticancer Research November 2013, 33 (11) 4757-4766;
BRUCE C. CASTO
1Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
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  • For correspondence: bcasto@cph.osu.edu
THOMAS J. KNOBLOCH
1Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
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REBECCA L. GALIOTO
3University Laboratory Animal Resources, The Ohio State University, Columbus, OH, U.S.A.
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ZHANGSHENG YU
2Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
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BRENT T. ACCURSO
4Section of Oral and Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH, U.S.A.
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BLAKE M. WARNER
1Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, U.S.A.
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Abstract

Background/Aim: Oral cancer represents approximately 2.5% of all cancers in the United States, with five- and 10-year survival rates of 62% and 51%. In the present study, lyophilized strawberries (LS) were evaluated for their potential to inhibit tumorigenesis in the hamster cheek pouch (HCP) model of oral cancer and for their ability to modify expression of several genes relevant to oral cancer development. Materials and Methods: HCPs were painted three times a week for six weeks with 0.2% 7,12-dimethylbenz(a)anthracene (DMBA). Hamsters were given 5% or 10% LS in their diet prior to, during, and after, or only after carcinogen treatment. Animals were sacrificed 12 weeks from the beginning of DMBA treatment and the number of total lesions and tumors was determined. Results: A significant difference (p<0.01-0.04) in the number of tumors was found between the LS-treated groups and the carcinogen controls. Histological examination of HCPs revealed a significant reduction in mild and severe dysplasia following 12 weeks of treatment with LS. Molecular analysis revealed that genes related to tumor development were modulated by LS. Conclusion: These experiments support previous studies in HCP that demonstrated a chemopreventive activity by black raspberries and show, to our knowledge for the first time, that strawberries can inhibit tumor formation in an animal model of oral cancer.

  • Chemoprevention
  • oral cancer
  • strawberries
  • hamster cheek pouch
  • Received September 24, 2013.
  • Revision received October 21, 2013.
  • Accepted October 23, 2013.
  • Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 33 (11)
Anticancer Research
Vol. 33, Issue 11
November 2013
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Chemoprevention of Oral Cancer by Lyophilized Strawberries
BRUCE C. CASTO, THOMAS J. KNOBLOCH, REBECCA L. GALIOTO, ZHANGSHENG YU, BRENT T. ACCURSO, BLAKE M. WARNER
Anticancer Research Nov 2013, 33 (11) 4757-4766;

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Chemoprevention of Oral Cancer by Lyophilized Strawberries
BRUCE C. CASTO, THOMAS J. KNOBLOCH, REBECCA L. GALIOTO, ZHANGSHENG YU, BRENT T. ACCURSO, BLAKE M. WARNER
Anticancer Research Nov 2013, 33 (11) 4757-4766;
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Keywords

  • chemoprevention
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