Research ArticleClinical Studies

Phase I Trial of Carboplatin and Etoposide in Combination with Panobinostat in Patients with Lung Cancer

AHMAD A. TARHINI, HARIS ZAHOOR, BRIAN MCLAUGHLIN, WILLIAM E GOODING, JOHN C. SCHMITZ, JILL M. SIEGFRIED, MARK A. SOCINSKI and ATHANASSIOS ARGIRIS
Anticancer Research October 2013, 33 (10) 4475-4481;

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Figures

  • Figure 1.
    Figure 1.

    Effects of panobinostat in combination with carboplatin and etoposide on p21 expression. The expression of p21 increased with LBH589 in combination with carboplatin and etoposide in 3 out of 4 subjects.

  • Figure 2.
    Figure 2.

    Effects of panobinostat in combination with carboplatin and etoposide on HDAC1 and HDAC6 expression. An increase in the expression of HDAC1 and HDAC6 was seen in 3 out of 4 patients.

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Phase I Trial of Carboplatin and Etoposide in Combination with Panobinostat in Patients with Lung Cancer
AHMAD A. TARHINI, HARIS ZAHOOR, BRIAN MCLAUGHLIN, WILLIAM E GOODING, JOHN C. SCHMITZ, JILL M. SIEGFRIED, MARK A. SOCINSKI, ATHANASSIOS ARGIRIS
Anticancer Research Oct 2013, 33 (10) 4475-4481;
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