Article Figures & Data
Figures
- Figure 1.
Chemical structures of daunorubicin (DAU) and its new derivatives containing either a morpholine moiety (DAUFmor) or a hexamethyleneimine moiety (DAUFhex) in the amidine group.
- Figure 2.
Effects of daunorubicin (DAU), and its new derivatives containing either a morpholine moiety (DAUFmor) or a hexamethyleneimine moiety (DAUFhex) in the amidine group, on induction of apoptosis and necrosis in MOLT-4 and ML-1 cells. Representative dot plots for MOLT-4 cells (A) and ML-1 cells (B): i - apoptotic cells, ii - late apoptotic and necrotic cells, iii - live cells. The frequency of early apoptotic, late apoptotic and necrotic, and live MOLT-4 (C) and ML-1 cells (D). Values not significantly different at p<0.05 according to the Tukey's multiple range test: ●, ●, ● between the groups of leukemia cells treated with the anthracycline agents; # compared to controls; + between the time points.
- Figure 3.
Effects of daunorubicin (DAU), and its new derivatives containing either a morpholine moiety (DAUFmor) or a hexamethyleneimine moiety (DAUFhex) in the amidine group, on the mitochondrial membrane potential (MMP). Representative dot plots showing MOLT-4 cells (A) and ML-1 cells (B) with the high (R1) and low (R2) MMP values. The frequency of MOLT-4 (A) and ML-1 cells (B) with the high MMP values. Values not significantly different at p<0.05 according to the Tukey's multiple range test: ●, ●, ● between the groups of leukemia cells treated with the anthracycline agents; # compared to controls; + between the time points.
