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Research ArticleExperimental Studies

Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules

KATHERINE ANN SCOTT, SINI SHAH, ANGUS GEORGE DALGLEISH and WAI MAN LIU
Anticancer Research October 2013, 33 (10) 4373-4380;
KATHERINE ANN SCOTT
Department of Oncology, Division of Clinical Sciences, St. George's, University of London, London, U.K.
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SINI SHAH
Department of Oncology, Division of Clinical Sciences, St. George's, University of London, London, U.K.
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ANGUS GEORGE DALGLEISH
Department of Oncology, Division of Clinical Sciences, St. George's, University of London, London, U.K.
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WAI MAN LIU
Department of Oncology, Division of Clinical Sciences, St. George's, University of London, London, U.K.
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  • For correspondence: w.liu@sgul.ac.uk
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Abstract

Cannabinoids are the bioactive components of the Cannabis plant that display a diverse range of therapeutic qualities. We explored the activity of six cannabinoids, used both alone and in combination in leukaemic cells. Cannabinoids were cytostatic and caused a simultaneous arrest at all phases of the cell cycle. Re-culturing pre-treated cells in drug-free medium resulted in dramatic reductions in cell viability. Furthermore, combining cannabinoids was not antagonistic. We suggest that the activities of some cannabinoids are influenced by treatment schedules; therefore, it is important to carefully select the most appropriate strategy in order to maximise their efficacy.

  • Cannabinoids
  • drug combination
  • drug schedule
  • leukaemia

Footnotes

  • Conflicts of Interest

    KAS, SS and AGD have no conflict of interests. WML is in receipt of research funding from GW Pharmaceuticals Ltd.

  • Received July 16, 2013.
  • Revision received August 6, 2013.
  • Accepted August 8, 2013.
  • Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 33 (10)
Anticancer Research
Vol. 33, Issue 10
October 2013
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Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
KATHERINE ANN SCOTT, SINI SHAH, ANGUS GEORGE DALGLEISH, WAI MAN LIU
Anticancer Research Oct 2013, 33 (10) 4373-4380;

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Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
KATHERINE ANN SCOTT, SINI SHAH, ANGUS GEORGE DALGLEISH, WAI MAN LIU
Anticancer Research Oct 2013, 33 (10) 4373-4380;
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Keywords

  • cannabinoids
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  • leukaemia
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