Article Figures & Data
Figures
- Figure 1.
Response of control tumor xenografts to platinum compounds. Xenografts were initiated from A2780 cells as described in the Materials and Methods. Tumor-bearing animals received a single i.p. treatment with PBS (day 0) followed on day 7 (arrow) by carboplatin (50 mg/kg) (A) or cisplatin (7.2 mg/kg) (B). Each curve shows the tumor response of an individual animal.
- Figure 2.
Response of carboplatin pre-treated tumors to platinum compounds. Xenografts were initiated from A2780 cells as described in the Materials and Methods. Tumor-bearing animals received a single i.p. treatment with carboplatin (15 mg/kg) (day 0) followed on day 7 (arrow) by carboplatin (50 mg/kg) (A), or cisplatin (7.2 mg/kg) (B). Each curve shows the tumor response of an individual animal.
- Figure 3.
The resistant phenotype is maintained in transplanted tumors. Xenografts were initiated from A2780 cells as described in the Materials and Methods. Tumor-bearing mice received a single i.p. treatment with carboplatin (15 mg/kg) as in the experiment shown in Figure 2. The animals were sacrificed seven days later (without exposure to the high dose of the drug). The tumors were excised and transplanted into new mice as described in the Materials and Methods. After tumor growth was clearly established, the animals received a single i.p. treatment with carboplatin (50 mg/kg) (arrow). Each curve shows the tumor response of an individual animal.
- Figure 4.
Selenite prevents the induction of resistance by carboplatin. Xenografts were initiated from A2780 cells as described in the Materials and Methods. Tumor-bearing animals received a single i.p. treatment with carboplatin (15 mg/kg) (day 0) and 3 i.p. treatments with selenite (1.5 mg/kg) on days -1, 0 and +1, followed on day 7 (arrow) by carboplatin (50 mg/kg) (A) or cisplatin (7.2 mg/kg) (B). Each curve shows the tumor response of an individual animal.
- Figure 5.
The sensitive phenotype is maintained in transplanted tumors. Xenografts were initiated from A2780 cells as described in the Materials and Methods. Tumor-bearing mice received a single i.p. treatment with carboplatin (15 mg/kg) and 3 i.p. treatments with selenite (1.5 mg/kg), as in the experiment shown in Figure 4. The animals were sacrificed seven days later (without exposure to the high dose of the drug). The tumors were excised and transplanted into new mice as described in Materials and Methods. After tumor growth was clearly established, the animals received a single i.p. treatment with carboplatin (50 mg/kg) (arrow). Each curve shows the tumor response of an individual animal.
