Article Figures & Data
Figures
- Figure 1.
Case 1 of colonic adenocarcinoma and adenoma. The patient had undergone endoscopic mucosal resection. Colonic endoscopy was performed 12 years after sex-mismatched bone marrow transplantation. A: Endoscopic image. A flat elevation of approximately 10 mm was found in the sigmoidal colon. B: Haematoxylin and eosin-stained sample from colonic tumour of this patient; histological examination of the samples revealed a well-differentiated tubular adenocarcinoma in an adenoma (int, INFα, m, ly0, v0, and surgical margin negative). Original magnification: ×100.
- Figure 2.
Case 2 of colonic adenocarcinoma and adenoma. The colonic endoscopy was performed 11 years after sex-mismatched bone marrow transplantation. A: Endoscopic image. An Isp polyp of approximately 10 mm was found in the oral-side ascending colon. B: Haematoxylin and eosin (HE)-stained sample from the colonic tumour, shown in Figure 2A; the patient had undergone endoscopic mucosal resection (EMR), and the histological examination revealed a well-differentiated tubular adenocarcinoma in adenoma (int, INFβ, med, pM, ly0, v0, surgical margin-negative). Original magnification: ×100. C: Endoscopic image. A polyp of approximately 3 mm was found in the anal-side ascending colon. D: HE-stained sample from the colonic tumour shown in Figure 2C; the patient underwent EMR, and the histological examination revealed only adenoma (surgical margin-negative). Original magnification: ×100.
- Figure 3.
FISH analysis of samples from case 1. FISH signals, DAPI, CD45 signal (red), and cytokeratin (green) signals are shown in cancerous (A) and non-cancerous (B) areas. Yellow arrowheads indicate Y-chromosome-positive cells. Only a small percentage of cancerous epithelial cells (1.2%) and non-cancerous epithelial cells (1.4%) have Y-chromosome signals derived from the donor. The interstitial cells in the cancerous (A) and non-cancerous (B) epithelial cell lesions were comprised of almost all donor-derived CD45+ cells (approximately 76%). Original magnification: main image, ×100; inset, ×200.
- Figure 4.
FISH analysis of samples from case 2. FISH signals, DAPI, CD45 signals, and cytokeratin signals in a cancerous area. Yellow arrowheads indicate Y-chromosome-positive cells. Only a small percentage of cancerous epithelial cells (1.2%) and non-cancerous epithelial cells (1.5%) have Y-chromosome signals derived from the donor. The interstitial cells in the cancerous lesion comprised of almost all donor-derived CD45+ cells (approximately 80%). Original magnification: main image, ×100; inset, ×200.
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