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Research ArticleExperimental Studies

Pharmacokinetics of Intravenous Nitrosylcobalamin, an Antitumor Agent, in Healthy Beagle Dogs: A Pilot Study

ANNETTE M. SYSEL, WALTER I. HORNE, JÖRG M. STEINER, JAN S. SUCHODOLSKI and JOSEPH A. BAUER
Anticancer Research September 2012, 32 (9) 3749-3752;
ANNETTE M. SYSEL
1BNOAT Oncology, Inc., Akron Innovation Campus, Akron, OH, U.S.A.
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WALTER I. HORNE
2Northeast Ohio Medical University, Rootstown, OH, U.S.A.
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JÖRG M. STEINER
3Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, U.S.A.
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JAN S. SUCHODOLSKI
3Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX, U.S.A.
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JOSEPH A. BAUER
1BNOAT Oncology, Inc., Akron Innovation Campus, Akron, OH, U.S.A.
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  • For correspondence: jbauer{at}bnoat.com
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    Figure 1.

    Mean serum cobalamin (NO-Cbl) concentration-time profiles for 10, 20, and 40 mg/kg doses of nitrosylcobalamin administered intravenously to Beagle dogs. Data are expressed as mean±standard error of the mean (SEM).

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Anticancer Research
Vol. 32, Issue 9
September 2012
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Pharmacokinetics of Intravenous Nitrosylcobalamin, an Antitumor Agent, in Healthy Beagle Dogs: A Pilot Study
ANNETTE M. SYSEL, WALTER I. HORNE, JÖRG M. STEINER, JAN S. SUCHODOLSKI, JOSEPH A. BAUER
Anticancer Research Sep 2012, 32 (9) 3749-3752;

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Pharmacokinetics of Intravenous Nitrosylcobalamin, an Antitumor Agent, in Healthy Beagle Dogs: A Pilot Study
ANNETTE M. SYSEL, WALTER I. HORNE, JÖRG M. STEINER, JAN S. SUCHODOLSKI, JOSEPH A. BAUER
Anticancer Research Sep 2012, 32 (9) 3749-3752;
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