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Research ArticleExperimental Studies

Comparison of Genomic Signatures of Non-small Cell Lung Cancer Recurrence between Two Microarray Platforms

JOHN WEN-CHENG CHANG, NIEN-CHIH WEI, HUNG-JU SU, JIE-LEN HUANG, TSE-CHING CHEN, YI-CHENG WU, CHIH-TENG YU, MING-MO HOU, CHIA-HSUN HSIEH, JIA-JUAN HSIEH, CHIAO-EN WU, HSIN-YI CHENG, TODD HSU and TZU-HAO WANG
Anticancer Research April 2012, 32 (4) 1259-1265;
JOHN WEN-CHENG CHANG
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NIEN-CHIH WEI
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HUNG-JU SU
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JIE-LEN HUANG
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TSE-CHING CHEN
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YI-CHENG WU
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CHIH-TENG YU
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MING-MO HOU
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CHIA-HSUN HSIEH
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JIA-JUAN HSIEH
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CHIAO-EN WU
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HSIN-YI CHENG
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TODD HSU
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TZU-HAO WANG
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  • For correspondence: knoxtn{at}cgmh.org.tw
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    Figure 1.

    Functional networks of 16 individual lung cancer tumors. Some genes are labeled by aliases. The genes (blue circles) that were up-regulated in non-recurrent tumors (also listed in Table II) were generalized into the networks using the MetaCore program.

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    Figure 2.

    Different gene expression between recurrence (R) and non-recurrence (NR) groups in Affymetrix (A) and Illumina (B) platforms. There were 13 genes selected and identified in the Affymetrix platform, while 21 genes were found in the Illumina platform. Student t test (p<0.05, |NR-R|>1) was used.

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    Figure 3.

    Kaplan-Meier plot of disease-free survival (DFS) (A) and overall survival (OS) (B) for patients with high-risk versus low-risk tumors. The median DFS was 20.4 (95% CI=3.6 to 37.2) months and not reached, respectively. The median OS was 37 (95% CI=2.6 to 71.4) months and not reached, respectively.

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Anticancer Research
Vol. 32, Issue 4
April 2012
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Comparison of Genomic Signatures of Non-small Cell Lung Cancer Recurrence between Two Microarray Platforms
JOHN WEN-CHENG CHANG, NIEN-CHIH WEI, HUNG-JU SU, JIE-LEN HUANG, TSE-CHING CHEN, YI-CHENG WU, CHIH-TENG YU, MING-MO HOU, CHIA-HSUN HSIEH, JIA-JUAN HSIEH, CHIAO-EN WU, HSIN-YI CHENG, TODD HSU, TZU-HAO WANG
Anticancer Research Apr 2012, 32 (4) 1259-1265;

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Comparison of Genomic Signatures of Non-small Cell Lung Cancer Recurrence between Two Microarray Platforms
JOHN WEN-CHENG CHANG, NIEN-CHIH WEI, HUNG-JU SU, JIE-LEN HUANG, TSE-CHING CHEN, YI-CHENG WU, CHIH-TENG YU, MING-MO HOU, CHIA-HSUN HSIEH, JIA-JUAN HSIEH, CHIAO-EN WU, HSIN-YI CHENG, TODD HSU, TZU-HAO WANG
Anticancer Research Apr 2012, 32 (4) 1259-1265;
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