Article Figures & Data
Figures
- Figure 1.
A: Sensitivity of UM-SCC-23 and UM-SCC-23F/R cells treated with 5-FU. Dose-dependent effect of 5-FU on survival in both cell lines. Each data point is the mean of three independent experiments. Error bars show standard deviations. B: Sensitivity of UM-SCC 23 and UM-SCC 23 F/R cells treated with etodolac. Dose-dependent effect of etodolac on survival in both cell lines. Each data point is the mean of three independent experiments. Error bars show standard deviations. C: Sensitivity of UM-SCC-23 and UM-SCC-23F/R cells to treatment with 5-FU and etodolac (50 μg/ml). Dose-dependent effect of 5-FU and etodolac on survival in both cell lines. Each data point is the mean of three independent experiments. Error bars show standard deviations. **p<0.01, t-test.
- Figure 2.
A: Cytotoxic activity of 5-FU and etodolac combinations against UM-SCC-23 cells. Data shown are mean of triplicate determinations, with error bars representing SD. Experiments were repeated at least two times with similar results. B: Isobologram analysis of the data shown in (A). The IC50 values of each drug are plotted; the solid line represents an additive effect, while the values of the combination below this line indicate synergism of the combination.
- Figure 3.
Western blot analysis of cyclooxygenase-2 (COX-2) and thymidylate synthase (TS) expression on treatment of UM-SCC-23 and UM-SCC-23F/R cells with etodolac.
- Figure 4.
A: Sensitivity of UM-SCC-23 and UM-SCC-23F/R cells treated with 5-FU in the presence of IL-1β. Each data point is the mean of three independent experiments. Error bars show standard deviations. B: Sensitivities of UM-SCC-23 and UM-SCC-23F/R cells treated with 5-FU and etodolac in the presence of IL-1β. Each data point is the mean of three independent experiments. Error bars show standard deviations. *p<0.05, t-test.
- Figure 5.
Western blot analysis of cyclooxygenase-2 (COX-2) and thymidylate synthase (TS) expression on treatment with etodolac and interleukin-1β of UM-SCC-23 and UM-SCC-23F/R cells.
