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Review ArticleR

Sonodynamic Cancer Therapy: A Non-invasive and Repeatable Approach Using Low-intensity Ultrasound with a Sonosensitizer

HIROTOMO SHIBAGUCHI, HIROFUMI TSURU, MOTOMU KUROKI and MASAHIDE KUROKI
Anticancer Research July 2011, 31 (7) 2425-2429;
HIROTOMO SHIBAGUCHI
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  • For correspondence: shiba-h@fukuoka-u.ac.jp
HIROFUMI TSURU
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MOTOMU KUROKI
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MASAHIDE KUROKI
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Abstract

The low-intensity ultrasound that is used in clinical diagnoses, such as abdomen echo inspection, is a non-invasive treatment, and penetrates deeper into the body than light. Recently, sonodynamic therapy (SDT), which uses low-intensity ultrasound together with a sonosensitizer, has been developed for cancer therapy in applying such properties of ultrasound. So far, most sonosensitizers that have been developed are sensitive to light as well as ultrasound, implying that the shortcomings of photosensitizers used during photodynamic therapy, such as skin sensitivity, still need to be overcome in SDT. Some exceptions were, however, reported in recent studies in which sensitizers were activated mainly by ultrasound but not by light. Furthermore, recent in vivo studies have demonstrated that SDT with a sonosensitizer has a great potential as a non-invasive and repeatable treatment for cancer therapy.

  • Low-intensity ultrasound
  • sonodynamic therapy
  • sonosensitizers
  • review
  • Received April 7, 2011.
  • Revision received June 1, 2011.
  • Accepted June 2, 2011.
  • Copyright© 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 31 (7)
Anticancer Research
Vol. 31, Issue 7
July 2011
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Sonodynamic Cancer Therapy: A Non-invasive and Repeatable Approach Using Low-intensity Ultrasound with a Sonosensitizer
HIROTOMO SHIBAGUCHI, HIROFUMI TSURU, MOTOMU KUROKI, MASAHIDE KUROKI
Anticancer Research Jul 2011, 31 (7) 2425-2429;

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Sonodynamic Cancer Therapy: A Non-invasive and Repeatable Approach Using Low-intensity Ultrasound with a Sonosensitizer
HIROTOMO SHIBAGUCHI, HIROFUMI TSURU, MOTOMU KUROKI, MASAHIDE KUROKI
Anticancer Research Jul 2011, 31 (7) 2425-2429;
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    • Abstract
    • Ultrasound
    • Drug Delivery System and Gene Therapy with Ultrasound
    • Sonodynamic Therapy
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