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Research ArticleClinical Studies

Prognostic Significance of Peripheral Blood CD8highCD57+ Lymphocytes in Bladder Carcinoma Patients After Intravesical IL-2

DAINIUS CHARACIEJUS, VITA PAŠUKONIENĖ, JOHN J.L. JACOBS, RIMANTAS EIDUKEVIČIUS, FELIKSAS JANKEVIČIUS, NERINGA DOBROVOLSKIENĖ, MYKOLAS MAURICAS, R. JEROEN A. VAN MOORSELAAR and WILLEM DEN OTTER
Anticancer Research February 2011, 31 (2) 699-703;
DAINIUS CHARACIEJUS
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  • For correspondence: dainius.characiejus@gmail.com
VITA PAŠUKONIENĖ
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JOHN J.L. JACOBS
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RIMANTAS EIDUKEVIČIUS
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FELIKSAS JANKEVIČIUS
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NERINGA DOBROVOLSKIENĖ
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MYKOLAS MAURICAS
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R. JEROEN A. VAN MOORSELAAR
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WILLEM DEN OTTER
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Abstract

Background: The objective of this study was to evaluate the recurrence-preventing effect of intravesical instillations of interleukin-2 (IL-2) in patients with non-muscle-invasive bladder carcinoma. In addition, this study aimed to determine the significance of immune parameters for recurrence-free interval. Patients and Methods: Twenty-six patients with non-muscle-invasive bladder carcinoma were treated with intravesical instillations of IL-2 (Proleukin®, Novartis, formerly Chiron) in doses of 9×106 IU on 5 consecutive days, beginning on the second day after transurethral resection (TUR) of tumours. CD8highCD57+ lymphocytes in peripheral blood were determined before TUR and compared with the recurrence-free interval after treatment. Results: The multivariate analysis showed that CD8highCD57+ lymphocytes had a prognostic significance in combination with number of bladder tumours, prior recurrence rate and age of patients. Conclusion: Peripheral blood CD8highCD57+ lymphocytes have prognostic significance for recurrence-free survival in patients with non-muscle-invasive bladder carcinoma after TUR and intravesical IL-2.

  • Bladder carcinoma
  • interleukin-2
  • CD8highCD57+ lymphocytes
  • recurrences
  • Received December 31, 2010.
  • Revision received January 25, 2011.
  • Accepted January 25, 2011.
  • Copyright© 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 31 (2)
Anticancer Research
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February 2011
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Prognostic Significance of Peripheral Blood CD8highCD57+ Lymphocytes in Bladder Carcinoma Patients After Intravesical IL-2
DAINIUS CHARACIEJUS, VITA PAŠUKONIENĖ, JOHN J.L. JACOBS, RIMANTAS EIDUKEVIČIUS, FELIKSAS JANKEVIČIUS, NERINGA DOBROVOLSKIENĖ, MYKOLAS MAURICAS, R. JEROEN A. VAN MOORSELAAR, WILLEM DEN OTTER
Anticancer Research Feb 2011, 31 (2) 699-703;

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Prognostic Significance of Peripheral Blood CD8highCD57+ Lymphocytes in Bladder Carcinoma Patients After Intravesical IL-2
DAINIUS CHARACIEJUS, VITA PAŠUKONIENĖ, JOHN J.L. JACOBS, RIMANTAS EIDUKEVIČIUS, FELIKSAS JANKEVIČIUS, NERINGA DOBROVOLSKIENĖ, MYKOLAS MAURICAS, R. JEROEN A. VAN MOORSELAAR, WILLEM DEN OTTER
Anticancer Research Feb 2011, 31 (2) 699-703;
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