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Research ArticleClinical Studies

Heterogeneity of Primary Site Biopsies in Head and Neck Squamous Cell Carcinoma

SUSANNE MOERTEL, HANNS ACKERMANN, MEHRAN BAGHI, ANNE ECKARDT, JENS WAGENBLAST, TIMO STÖVER and MARKUS HAMBEK
Anticancer Research February 2011, 31 (2) 665-669;
SUSANNE MOERTEL
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  • For correspondence: susanne.moertel{at}kgu.de
HANNS ACKERMANN
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MEHRAN BAGHI
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ANNE ECKARDT
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JENS WAGENBLAST
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TIMO STÖVER
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MARKUS HAMBEK
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    Figure 1.

    EGRF expression in the superficial biopsies and the core biopsies compared with that in the cross-sections. The different biopsies were taken of 24 tumour preparations of head and neck cancer. There was a significant difference in the EGFR expression between the superficial biopsy and the cross-section through the tumour (p=0.013). The same was shown in the comparison between the EGFR expression of the core biopsy and that of the cross-section through the tumour (p=0.036).

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    Figure 2.

    The expression of Ki-67 in the superficial biopsies and the core biopsies compared with that in the cross-sections. The different biopsies were taken of 24 tumour preparations of head and neck cancer. There was no significant difference in the Ki-67 expression between the superficial biopsy and the cross-section through the tumour (p=0.153). There was a significant difference between the core biopsy and the cross-section in the Ki-67 expression.

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    Figure 3.

    EGFR-positive tumour cells in the 24 superficial biopsies, 24 core biopsies and 24 tumour cross-sections.

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    Figure 4.

    Ki-67-positive tumour cells in the 24 superficial biopsies, 24 core biopsies and 24 tumour cross-sections.

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    Figure 5.

    Illustration of how the biopsies were taken. The core biopsy was taken using a 16-gauge needle with a length of 20 mm and a diameter of 1.6 mm. The superficial biopsies had a size of 3 mm.

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Anticancer Research
Vol. 31, Issue 2
February 2011
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Heterogeneity of Primary Site Biopsies in Head and Neck Squamous Cell Carcinoma
SUSANNE MOERTEL, HANNS ACKERMANN, MEHRAN BAGHI, ANNE ECKARDT, JENS WAGENBLAST, TIMO STÖVER, MARKUS HAMBEK
Anticancer Research Feb 2011, 31 (2) 665-669;

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Heterogeneity of Primary Site Biopsies in Head and Neck Squamous Cell Carcinoma
SUSANNE MOERTEL, HANNS ACKERMANN, MEHRAN BAGHI, ANNE ECKARDT, JENS WAGENBLAST, TIMO STÖVER, MARKUS HAMBEK
Anticancer Research Feb 2011, 31 (2) 665-669;
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