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Review ArticleClinical StudiesR

Prediction of Response in Cancer Immunotherapy

DAINIUS CHARACIEJUS, JOHN J.L. JACOBS, VITA PAŠUKONIENĖ, NIJOLĖ KAZLAUSKAITĖ, VITA DANILEVIČIŪTĖ, MYKOLAS MAURICAS and WILLEM DEN OTTER
Anticancer Research February 2011, 31 (2) 639-647;
DAINIUS CHARACIEJUS
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  • For correspondence: dainius.characiejus@gmail.com
JOHN J.L. JACOBS
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VITA PAŠUKONIENĖ
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NIJOLĖ KAZLAUSKAITĖ
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VITA DANILEVIČIŪTĖ
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MYKOLAS MAURICAS
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WILLEM DEN OTTER
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Abstract

This review focuses on the relationship between pre-treatment immune parameter values and outcome of immunotherapy of cancer patients. The evidence presented in this review suggests that there is a relationship between pre-treatment immune parameter values and survival of cancer patients treated with immunotherapy. Tumour-infiltrating immune cells may have a predictive value for immunotherapy, but predictive power might be obtained from peripheral blood leukocytes. Use of peripheral blood may be preferable due to the convenience of collection and analysis compared to using tumour-infiltrating cells. In vivo numbers of cells of the immune system correlate better with clinical outcome than their functional activity ex vivo. This suggests that immunological antitumour mechanisms in vivo are not always related to generally accepted functional parameters of lymphocytes, such as cytotoxicity or cytokine production, ex vivo. The proliferative status of CD8+ T lymphocytes seems promising for prediction of response in cancer immunotherapy.

  • Cancer
  • immunotherapy
  • prediction
  • survival
  • CD8
  • CD57
  • review
  • Received December 30, 2010.
  • Revision received January 25, 2011.
  • Accepted January 25, 2011.
  • Copyright© 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 31 (2)
Anticancer Research
Vol. 31, Issue 2
February 2011
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Prediction of Response in Cancer Immunotherapy
DAINIUS CHARACIEJUS, JOHN J.L. JACOBS, VITA PAŠUKONIENĖ, NIJOLĖ KAZLAUSKAITĖ, VITA DANILEVIČIŪTĖ, MYKOLAS MAURICAS, WILLEM DEN OTTER
Anticancer Research Feb 2011, 31 (2) 639-647;

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Prediction of Response in Cancer Immunotherapy
DAINIUS CHARACIEJUS, JOHN J.L. JACOBS, VITA PAŠUKONIENĖ, NIJOLĖ KAZLAUSKAITĖ, VITA DANILEVIČIŪTĖ, MYKOLAS MAURICAS, WILLEM DEN OTTER
Anticancer Research Feb 2011, 31 (2) 639-647;
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  • Article
    • Abstract
    • Prediction of Response to Bacillus Calmette-Guérin Immunotherapy
    • Prediction of Response to Cytokine Therapy
    • Prediction of Response to Monoclonal Antibody Therapy
    • Prediction of Response to Vaccination Therapy
    • Prediction of Response to Adoptive Cell Immunotherapy
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