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Research ArticleClinical Studies

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention

CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY and ROBERT P. HEANEY
Anticancer Research February 2011, 31 (2) 607-611;
CEDRIC F. GARLAND
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CHRISTINE B. FRENCH
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LEO L. BAGGERLY
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ROBERT P. HEANEY
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  • For correspondence: rheaney{at}creighton.edu
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    Figure 1.

    Frequency distribution of individual vitamin D daily doses among 3,667 participants. Each bar shows the number of participants ingesting a dose up to the specified magnitude and greater than the next lower daily input. (Copyright Robert P. Heaney, 2011. Used with permission)

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    Figure 2.

    Serum 25(OH)D as a function of daily vitamin D intake, together with the best fit line to Eq. 1, its confidence limits, and the 95% probability band (outer dashed lines) for the entire cohort. For convenience in reading, the exponential constant and the coefficient of the linear term in the equation are in units of 1,000 IU/d. (Copyright Robert P. Heaney, 2011. Used with permission)

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    Figure 3.

    Plot of the expected rise in serum 25(OH)D for every 1,000 IU vitamin D3 supplemented daily, as a function of basal 25(OH)D value. (Copyright Robert P. Heaney, 2011. Used with permission.)

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    Figure 4.

    Plot of the regression line from Figure 2 on previously published high-dose data (8). Note that the horizontal axis is logarithmic. The diamond-shaped symbols are the means of controlled dosing studies (n=48) and the square symbols, individual values from reported cases (n=21) of vitamin D intoxication. (Copyright Robert P. Heaney, 2011. Used with permission)

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Anticancer Research
Vol. 31, Issue 2
February 2011
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Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY, ROBERT P. HEANEY
Anticancer Research Feb 2011, 31 (2) 607-611;

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Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY, ROBERT P. HEANEY
Anticancer Research Feb 2011, 31 (2) 607-611;
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