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Research ArticleClinical Studies

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention

CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY and ROBERT P. HEANEY
Anticancer Research February 2011, 31 (2) 607-611;
CEDRIC F. GARLAND
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CHRISTINE B. FRENCH
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LEO L. BAGGERLY
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ROBERT P. HEANEY
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  • For correspondence: rheaney@creighton.edu
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Abstract

Background: Studies indicate that intake of vitamin D in the range from 1,100 to 4,000 IU/d and a serum 25-hydroxyvitamin D concentration [25(OH)D] from 60-80 ng/ml may be needed to reduce cancer risk. Few community-based studies allow estimation of the dose–response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d. Materials and Methods: A descriptive study of serum 25(OH)D concentration and self-reported vitamin D intake in a community-based cohort (n=3,667, mean age 51.3±13.4 y). Results: Serum 25(OH)D rose as a function of self-reported vitamin D supplement ingestion in a curvilinear fashion, with no intakes of 10,000 IU/d or lower producing 25(OH)D values above the lower-bound of the zone of potential toxicity (200 ng/ml). Unsupplemented all-source input was estimated at 3,300 IU/d. The supplemental dose ensuring that 97.5% of this population achieved a serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d. Conclusion: Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity.

  • Serum 25(OH)D
  • vitamin D
  • toxicity
  • chemoprevention
  • Received December 22, 2010.
  • Revision received January 18, 2011.
  • Accepted January 19, 2011.
  • Copyright© 2011 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 31 (2)
Anticancer Research
Vol. 31, Issue 2
February 2011
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Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY, ROBERT P. HEANEY
Anticancer Research Feb 2011, 31 (2) 607-611;

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Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND, CHRISTINE B. FRENCH, LEO L. BAGGERLY, ROBERT P. HEANEY
Anticancer Research Feb 2011, 31 (2) 607-611;
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