Article Figures & Data
Figures
- Figure 1.
TINZ and S-NACH inhibit tumor growth and angiogenesis in the chick chorioallantoic membrane (CAM) model of angiogenesis and tumor growth. (A) Tumor weight (g) and (B) Hb level (mg/ml) as an index of tumor vascularity are shown. For the Dox groups, TINZ and S-NACH were given at 2.5 mg/ml (51 ug/CAM), and Dox was administered at 0.625 mg/ml (6.25 μg/CAM). For the PACL groups, PACL was given at 0.5 mg/ml (5 μg/CAM) and TINZ and S-NACH were given at 1 mg/ml (20 μg/CAM). Data are expressed as means±SEM (n=6).
- Figure 2.
TINZ and S-NACH inhibit tumor growth in a mouse xenograft model of lung cancer. Tumor volume over time (A) and tumor weight at the conclusion of the experiment (B) are shown. Data represent means±SEM (n=4).
- Figure 3.
Antitumor efficacy of PACL with or without LMWH. (A) Results of a 14-day treatment protocol consisting of PACL or TINZ alone or their combination. Data are expressed as median tumor volume (mm3), n=3. Tumor growth curves of (B) untreated (Control) and (C) PACL-treated (PACL) animals (n=4 and 7, respectively) were followed after termination of treatment. The treatment protocol was as described for (A). Individual tumor growth curves are shown for each animal. Three of the seven mice in the PACL group demonstrated tumor regrowth after discontinuation of treatment on day 14.
- Figure 4.
LMWH compounds increase uptake of chemotherapeutic agent by Dox-resistant breast tumor xenografts. Mice were pre-treated with 10 mg/kg TINZ or S-NACH for five days followed by Dox (2.5 mg/kg). Three (upper panels) or 24 h later (lower panels), animals were euthanized and tissues obtained for HPLC determination of Dox. *p<0.05 versus Dox alone.
Tables
In this issue
Jump to section
Related Articles
Cited By...
- No citing articles found.