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Research ArticleExperimental Studies

Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-κB Signalling

SAADIA BASHIR HASSAN, HALA GALI-MUHTASIB, HANNA GÖRANSSON and ROLF LARSSON
Anticancer Research June 2010, 30 (6) 1911-1919;
SAADIA BASHIR HASSAN
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  • For correspondence: sadia.hassan@medsci.uu.se
HALA GALI-MUHTASIB
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HANNA GÖRANSSON
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ROLF LARSSON
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Abstract

Background: Alpha terpineol is a bioactive component of Salvia libanotica essential oil extract and has shown antitumour activity. Materials and Methods: The cytotoxicity of alpha terpineol towards different tumour cell lines was evaluated in vitro. Mechanistic characterization was performed using analysis of drug activity in a cell line panel and drug-induced gene expression perturbation using the connectivity map approach. Results: The small cell lung carcinoma was the cell line most sensitive to alpha terpineol. The results proposed alpha terpineol as an NF-κB inhibitor, which was confirmed by the observed dose-dependent inhibition of NF-κB translocation and activity using two NF-κB assays, and by the down-regulation of the expression of several NF-κB-related genes such as IL-1β and IL1R1. Conclusion: The results suggest that alpha terpineol inhibits the growth of tumour cells through a mechanism that involves inhibition of the NF-κB pathway.

  • Alpha terpineol
  • Salvia libanotica
  • NF-κB
  • connectivity map

Footnotes

  • Copyright© 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 30 (6)
Anticancer Research
Vol. 30, Issue 6
June 2010
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Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-κB Signalling
SAADIA BASHIR HASSAN, HALA GALI-MUHTASIB, HANNA GÖRANSSON, ROLF LARSSON
Anticancer Research Jun 2010, 30 (6) 1911-1919;

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Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-κB Signalling
SAADIA BASHIR HASSAN, HALA GALI-MUHTASIB, HANNA GÖRANSSON, ROLF LARSSON
Anticancer Research Jun 2010, 30 (6) 1911-1919;
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