Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Subscribers
    • Advertisers
    • Editorial Board
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Mental Neuropathy (Numb Chin Syndrome) Leading to Diagnosis of Metastatic Mediastinal Cancer

REINHARD E. FRIEDRICH
Anticancer Research May 2010, 30 (5) 1819-1821;
REINHARD E. FRIEDRICH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: rfriedrich@uke.uni-hamburg.de
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Neuropathy of the mental nerve is a rare condition that demands accurate differential diagnosis. A 69-year-old male experienced progressive hypoaesthesia of the right side of the corner of the mouth and chin, associated with intermittent phases of pain. Plain radiographs and computerised tomography (CT) scans revealed the mental foramen on the top of the toothless mandible and a symmetrically depicted mandibular canal. Surgical exploration demonstrated a tumour inside the mandibular canal, not visible on radiographs. Subsequently performed CT scans revealed an extensive mediastinal tumour with metastasis to multiple lymph nodes and further metastases to the kidney and liver. Diagnosis was small-cell bronchial carcinoma (extensive disease, stage grouping II B, Marburg classification). Palliative chemotherapy was ineffective and the patient died with evidence of tumour progression. The cause of a numb chin needs to be clarified further, and the syndrome should be seriously considered, using thorough diagnosis, including the surgical revision of the affected nerve.

  • Numb chin syndrome
  • mental neuropathy
  • mandibular metastasis
  • inferior alveolar nerve
  • orthopantomogram

Neuropathy of the mental nerve, also referred to as “numb chin” syndrome, is a rare finding that demands accurate differential diagnosis (1). The finding of a numb chin in a patient with no history of maxillofacial trauma or other obvious dental or osseous diseases as the cause of nerve damage (e.g. oral cancer with mandibular invasion) is more often associated with cancer as the first symptom of metastasis than with non-cancerous conditions, such as multiple sclerosis (2), temporal arteritis (3) and blood disease (4). Mental neuropathy as the initial symptom of a malignant disease has been documented in many types of cancer, predominantly in case reports or small studies (5-19). The organs of origin in patients with neuropathy of the mental nerve due to metastasis are the breast, lung, kidney, thyroid, prostate and stomach (11). Metastatic tumours from these organs are by far the most frequent sites of distant metastasis to the maxillofacial region, associated with a late and usually fatal stage of the malignant disease (6). Rarely other types of cancer may also cause a numb chin by this way of action: ovary (13), multiple myeloma (14), mucoepidermoid carcinoma (15), Burkitt lymphoma (16-18) or acute leukaemia (19). This is a case report about a patient with a unilateral numb chin as the initial symptom of a metastasizing large mediastinal small-cell carcinoma.

Case Report

A 69-year-old male experienced progressive hypoaesthesia of the right side of the corner of the mouth and chin, associated with intermittent phases of pain about 4 weeks prior to hospital admission. On admission, the patient located the pain at the mental foramen, with centripetal projection along the nerve route inside the mandible. A computerised tomographic (CT) scan of the brain had been performed prior to admission and had excluded acute cerebral lesions. Supratentorial lesions were related to the patient's history of stroke at the age of 58 years. A further CT scan of the neck had been performed to exclude pterygomandibular tumour, with no specific findings. A plain chest radiograph had demonstrated age-dependent findings but no space-occupying lesions. The patient was toothless and a possible cause of the pain could have been his dental prosthesis. An orthopantomogram revealed the mental foramen on the top of the mandible and a symmetrically depicted mandibular canal. Whereas the location of the foramina supported the view of a mechanical pressure as a putative cause of triggering the pain, the laterality of the symptom was hardly explained, and the patient did not wear his prosthesis for a long time. Moreover, anaesthesia was almost complete in the right mental nerve region. The medical history of the patient disclosed lung tuberculosis at the age of 23 years, a parotidectomy for pleomorphic adenoma at the age of 37 years, and chronic obstructive pulmonary disease. The patient had stopped smoking at the age of 43.

Figure 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1.

Orthopantomogram of the patient at the time of admission. The toothless jaws show no osteolysis. The mental foramina are located in the level of the mandibular height and subject to occlusal pressure from dental prosthesis. Distal to the right mental foramen, a metallic foreign body is depicted. This foreign body was removed and was not the cause of the numb chin (Figure 2).

Figure 2.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2.

The metallic foreign body became evident after removal of the mucoperiosteal flap from the bone of the right mandibular corpus (arrow). Histology revealed a granulation tissue with foreign body reaction compatible with metallic residues from former dental restorations.

A revision surgery of the nerve was decided in order to relieve the nerve from direct chewing pressure and to exclude other causes of the neuropathy. However, after osteotomy and exposing the inferior alveolar nerve in the mandibular canal, a greyish mass was detected, invading the nerve and running like a cuff around the nerve and inside the canal. The tumour ran along the nerve proximally up to the inner mandibular angle. Intraoperatively, a frozen section of the tumour was diagnosed as granulation and scary tissue. However, the clinical aspect supported the tentative diagnosis of malignant disease. The tumour was scraped from the nerve. In some sites, the tumour obviously adhered to the nerve bundle but not to the bone. The nerve was lateralised to the vestibulum and the wound was closed by primary intention. Histological investigation of the tumour samples revealed a small-cell carcinoma, probably of bronchial origin. The tumour cells were immunoreactive for NSE and sporadically EMA-positive, negative for LCA and chromogranin. A CT scan of the chest revealed an extensive mediastinal tumour (dimensions: 7.6 × 6.2 × 8 cm) with multiple retrosternal, pretracheal and subcarinal lymph nodes. Further metastases were found in the kidney and liver. Clinical diagnosis was small-cell bronchial carcinoma (extensive disease, stage grouping II B, Marburg classification). A bronchoscopy did not provide aspirates indicative of the tumour. A skeletal scintigraphy disclosed multiple spots of the bones suspected as bone metastases. Palliative chemotherapy was decided and started with carboplatin and etoposide. Bonefos (1500 mg/6 h) was administered once a month to stop further bone invasion. Despite these measures, tumour progression became evident after 2 months, indicated by mediastinal and hepatic tumour growth. Further chemotherapy (topisomerase inhibitor RFS (9-nitro-camptothecin, 9 NC), EORTC study 16996L) was stopped after 4 weeks, being ineffective. Alternatively, doxorubicin and cyclophosphamide were applied (4 cycles). However, 6 months after initial diagnosis, the patient died with evidence of tumour progression, both mediastinal and hepatic, and in the mandibular angle.

Figure 3.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 3.

Aspect of the mandibular canal after osteotomy of the canal's roof. The mental foramen was resected. The mandibular nerve runs inside the canal with some space for passive movements (bilateral arrow shows the long axis of the nerve). Cranial to the nerve, the greyish tumour can be seen to adhere to the nerve (small arrow), but not to the bone.

Discussion

This report described the fatal course of a patient with numb chin syndrome and the need for surgical exploration to establish diagnosis.

According to Lossos and Siegal, mental neuropathy following metastasis to the third branch of the trigeminal nerve occurs late in the disease (6). These authors evaluated 42 patients with numb chin syndrome and discussed several mechanisms for the symptoms: (i) compression of the mental or inferior alveolar nerve by metastasis to the mandible (20), (ii) metastases to the skull base, and (iii) leptomeningeal spread (12). However, in the patient of this report, neither the CT scan nor the orthopantomogram of the jaws were able to show the tumour. Diagnosis was achieved after surgical revision. Primary and further metastases were detected by means of CT scans and scintigraphy. These methods are recommended for staging in numb chin syndrome with evidence of metastasis (19). Indeed, the lack of radiographic tumour imaging is an indicator of rapid tumour growth: a widening of the inferior alveolar canal is likely to be associated with a slowly growing tumour (21). It is, therefore, recommended that a numb chin without any history of other diseases associated with dissociation of sensory disorders, no evidence of head and neck tumour by imaging techniques and with the lesion being confined to lips and chin, should be explored surgically.

Conclusion

Numb chin syndrome is rare and not well-appreciated as a serious finding in the field of oral and maxillofacial surgery (22). Indeed, dysaesthesia of the mental nerve is frequently associated with obvious dental findings (poor retention of dental prosthesis, diseases of the dental apices affecting the inferior alveolar nerve). In certain cases, the history of trauma passes the differential diagnosis in the accurate direction. This report demonstrated that the cause of a numb chin needs to be clarified further, and the syndrome should be taken seriously, using thorough diagnostics, including the surgical revision of the affected nerve.

Footnotes

  • Received August 19, 2009.
  • Revision received April 6, 2010.
  • Accepted April 9, 2010.
  • Copyright© 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

References

  1. ↵
    1. Bar-Ziv J,
    2. Slasky BS
    : CT imaging of mental nerve neuropathy: the numb chin syndrome. Am J Roentgenol 168: 371-376, 1997.
    OpenUrlPubMed
  2. ↵
    1. Oestmann A,
    2. Achtnichts L,
    3. Kappos L,
    4. Gass A,
    5. Naegelin Y
    : “Numb chin syndrome”: first presenting syndrome of multiple sclerosis? Dtsch Med Wochenschr 133: 76-78, 2008 (in German).
    OpenUrlPubMed
  3. ↵
    1. Abilleira S,
    2. Bowler JV
    : The numb chin syndrome as an early manifestation of giant-cell (temporal) arteritis: a case report. Headache 45: 1411-1413, 2005.
    OpenUrlPubMed
  4. ↵
    1. Mestoudjian P,
    2. Steichen O,
    3. Stankovic K,
    4. Lecomte I,
    5. Lionnet F
    : Sickle cell disease, a benign cause of numb chin syndrome. Am J Med 121: e1, 2008.
    OpenUrlPubMed
  5. ↵
    1. Massey EW,
    2. Moore J,
    3. Schold SC Jr
    : Mental neuropathy from systemic cancer. Neurology 31: 1277-1281, 1981.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    1. Lossos A,
    2. Siegal T
    : Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance. Neurology 42: 1181-1184, 1992.
    OpenUrlAbstract/FREE Full Text
    1. Fenaux P,
    2. Lai JL,
    3. Miaux O,
    4. Zandecki M,
    5. Jouet JP,
    6. Bauters F
    : Burkitt cell acute leukaemia (L3 ALL) in adults: a report of 18 cases. Br J Haematol 71: 371-376, 1989.
    OpenUrlPubMed
    1. Lynch TC Jr,
    2. McCloud TC,
    3. Harris NL
    : Case 27-1994. Case records of the Massachusets General Hospital. N Engl J Med 331: 107, 1994.
    OpenUrlCrossRefPubMed
    1. Newman NJ
    : Multiple cranial neuropathies: presenting signs of systemic lymphoma. Surv Ophthalmol 37: 125-129, 1992.
    OpenUrlCrossRefPubMed
    1. Kuroda Y,
    2. Fujiyama F,
    3. Ohyama T,
    4. Watanabe T,
    5. Endo C,
    6. Neshige R,
    7. Kakigi R
    : Numb chin syndrome secondary to Burkitt's cell acute leukemia. Neurology 41: 453-454, 1991.
    OpenUrlAbstract/FREE Full Text
  7. ↵
    1. Burt RK,
    2. Sharfman WH,
    3. Karp BI,
    4. Wilson WH
    : Mental neuropathy (numb chin syndrome). A harbinger of tumor progression or relapse. Cancer 70: 877-881, 1992.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Hashimoto N,
    2. Kurihara K,
    3. Yamasaki H,
    4. Ohba S,
    5. Sakai H,
    6. Yoshida S
    : Pathological characteristics of metastatic carcinoma in the human mandible. J Oral Pathol 16: 362-367, 1987.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Eppley BL,
    2. Snyders RV Jr
    : Mental neuropathy as a sign of distant malignancy: report of cases. J Oral Maxillofac Surg 50: 1117-1119, 1992.
    OpenUrlPubMed
  10. ↵
    1. Vincent SD,
    2. Lilly GE,
    3. Hupp JR
    : Paresthesia of the mandibular division, trigeminal nerve. J Oral Maxillofac Surg 51: 565-569, 1993.
    OpenUrlPubMed
  11. ↵
    1. Vincent SD,
    2. White RD
    : Progressive paresthesia of the trigeminal nerve. J Oral Maxillofac Surg 51:70-74, 1993.
    OpenUrlPubMed
  12. ↵
    1. Sariban E,
    2. Donahue A,
    3. Magrath IT
    : Jaw involvement in American Burkitt's lymphoma. Cancer 53: 1777-1782, 1984.
    OpenUrlPubMed
    1. Patton LL,
    2. McMillan CW,
    3. Webster WP
    : American Burkitt's lymphoma: a 10-year review and case study. Oral Surg Oral Med Oral Pathol 69: 307-316, 1990.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Anavi Y,
    2. Kaplinsky C,
    3. Calderon S,
    4. Zaizov R
    : Head, neck, and maxillofacial childhood Burkitt's lymphoma: a retrospective analysis of 31 patients. J Oral Maxillofac Surg 48: 708-713, 1990.
    OpenUrlPubMed
  14. ↵
    1. Kuklok KB,
    2. Burton RG,
    3. Wilhelm ML
    : Numb chin syndrome leading to a diagnosis of acute lymphoblastic leukemia: report of a case. J Oral Maxillofac Surg 55: 1483-1485, 1997.
    OpenUrlPubMed
  15. ↵
    1. Biasotto M
    : Numb chin syndrome as the presenting symptom of carcinomatous meningitis. Ann Oncol 19: 599-601, 2008.
    OpenUrlFREE Full Text
  16. ↵
    1. Vartiainen VM,
    2. Siponen M,
    3. Salo T,
    4. Rosberg J,
    5. Apaja-Sarkkinen M
    : Widening of the inferior alveolar canal: a case report with atypical lymphocytic infiltration of the nerve. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106: e35-39, 2008.
    OpenUrlPubMed
  17. ↵
    1. Smith SF,
    2. Blackman G,
    3. Hopper C
    : Numb chin syndrome: a nonmetastatic neurological manifestation of malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105: e53-56, 2008.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

Anticancer Research: 30 (5)
Anticancer Research
Vol. 30, Issue 5
May 2010
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Mental Neuropathy (Numb Chin Syndrome) Leading to Diagnosis of Metastatic Mediastinal Cancer
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
10 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Mental Neuropathy (Numb Chin Syndrome) Leading to Diagnosis of Metastatic Mediastinal Cancer
REINHARD E. FRIEDRICH
Anticancer Research May 2010, 30 (5) 1819-1821;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Mental Neuropathy (Numb Chin Syndrome) Leading to Diagnosis of Metastatic Mediastinal Cancer
REINHARD E. FRIEDRICH
Anticancer Research May 2010, 30 (5) 1819-1821;
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Case Report
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Symptomatic Mandibular Fibrous Dysplasia With Concurrent Triple X- and Premutation Stage Fragile-X-Syndrome: Case Report With Short Literature Survey
  • Unilaterally Enlarged Mandibular Foramina and Canal Associated With Hyperplastic Lymphatic Tissue of Inferior Alveolar Nerve: Case Report and Short Literature Survey
  • Cone Beam Computed Tomography in the Differential Diagnosis of Mental Neuropathy (Numb Chin Syndrome) in Metastatic Colon Cancer
  • Non-Hodgkin lymphoma presenting with numb chin syndrome
  • Google Scholar

More in this TOC Section

  • Feasibility of Computed Tomography-guided Percutaneous Renal Cryoablation Under Local Anesthesia: A Single Center Experience in Taiwan
  • Conversion Surgery for Unresectable Pancreatic Cancer Treated With FOLFIRINOX or Gemcitabine Plus Nab-paclitaxel
  • Gastric Linitis Plastica: Clinical Characteristics and Outcomes from the National Cancer Database
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2023 Anticancer Research

Powered by HighWire