Protein Engineering and Design.

Edited by S.J. Park, , J.R. Cochran. . 2010, pp. 402, £76.99, ISBN: 978-1-4200-7658-5. CRC Press / Taylor & Francis Group, Boca Raton, FL, USA.

Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, this volume aims to cultivate a synergistic approach to protein science.

Exploring the most important strategies used by protein scientists, including experimental protein engineering and computational protein design, this volume examines: High-throughput screening platforms for protein engineering; Key techniques used for diversity generation; The use of non-natural amino acids in protein engineering; Computational and informatics algorithms used in protein engineering; Core principles of computational protein design; Heuristic protein design; Examples of therapeutics, enzymes, biomaterials, and other proteins that are engineered by rational or combinatorial approaches; Engineered proteins that exemplify the use of both computational and combinatorial methods.

Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike.