Article Figures & Data
Figures
- Figure 1.
Effect of treatment regimen on survival in mice transplanted orthotopically with GFP-HCT-116. a, Control group; b, 5-FU + LV group; c, 5-FU + LV + CPT-11 (16 mg/kg) group; d, 5-FU + LV + CPT11 (24 mg/kg) group, p<0.0001 (a vs. c, b vs. d).
- Figure 2.
Histological observation of liver in mice transplanted orthotopically with GFP-HCT-116 (H & E staining, ×40). Cont.: Control; 5-FU/LV: 5-FU + LV; 5-FU + LV + CPT-11 (16 mg/kg); 5-FU + LV + CPT-11 (24 mg/kg). Tumor in the liver of the control mouse was large and abundant in blood vessels (upper left micrograph). Tumor in mouse treated with 5-FU/LV was small, with necrosis in parts (arrow in upper right micrograph). Tumor in mouse treated with CTP-11 at 16 mg was smaller than in the former two (arrows in lower left micrograph). Tumor in mouse treated with CPT-11 at 24 mg/kg was extremely small (arrow in lower right micrograph) and the central area was almost necrotic.
- Figure 3.
Expression of cancer genes in mesenteric lymph nodes of mice transplanted orthotopically with human colon cancer line, GFP-HCT-116. See Materials and Methods for details.
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