Detection of Vimentin (VIM) Methylation in the Serum of Colorectal Cancer Patients

Of 44 colorectal cancer patients, 31 (70%) exhibited a methylation of VIM in their serum DNA by qMSP. However, 10 out of these 31 patients exhibited no VIM methylation in their tumors. Therefore, we considered that the findings of VIM methylation in serum derived from 4 colorectal cancer patients who also exhibited VIM methylation in their tumor and a higher methylation level in their serum than these 10 patients were truly positive.