Article Figures & Data
Figures
- Figure 1.
The structure of 1,2,3,4-tetrahydroisoquinoline derivatives. (A) TQ1-19, (B) TD1-19.
- Figure 2.
Induction of DNA fragmentation by two 2-aminotropolone derivatives. Near confluent HL-60 (A, B) or HSC-2, HSC-4 cells (C) were incubated for 6 or 24 hours with the indicated concentrations of TQ9 (A, C) or TD13 (B). DNA was then extracted and applied to agarose gel electrophoresis. M: Marker DNA. UV, DNA from the HL-60 cells exposed to 1-min UV irradiation (32).
- Figure 3.
Effect of TQ9 on caspase-3 activity. Near confluent HSC-2, HC-4 and HL-60 cells were incubated for 6 hours with the indicated concentrations of TQ9, or exposed to 1 min UV irradiation followed by 6 hours inculation (32). Each point represents the mean±S.D. from triplicate assays. Significance between control and treated cells: *p=0.046, **p=0.137.
- Figure 4.
Induction of the production of acidic organelles by TQ9. HSC-2 (A-D) and HSC-4 cells (E-H) were incubated for 6 hours without (A, E) or with 40 (B), 60 (F), 80 (C), or 120 (G) μM TQ9 in DMEM+10% FBS, or for 1 hour in Hank's balanced salt solution (D, H). The cells were stained with acridine orange for the detection of acidic organelles.
