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Figures
- Figure 1.
Chemical structure of benzo[b]cyclohepta[e][1,4]benzoxazines and their S-analogs [1-8], and 2-aminotropones [9-20].
- Figure 2.
Induction of DNA fragmentation by two 2-aminotropolones derivatives. Near confluent HSC-2 (A, B) and HL-60 cells (C, D) were incubated for 6, 24 or 48 hours with the indicated concentrations of [16] (A, C) or [20] (B, D). DNA was then extracted and applied to agarose gel electrophoresis. M: Marker DNA. UV, DNA from apoptotic HL-60 cells induced by UV irradiation (38). One representative data from three independent experiments are shown.
- Figure 3.
Activation of caspases-3, -8 and -9 by two 2-aminotropolone derivatives. Near confluent HSC-2 (A, B) and HL-60 cells (C, D) were incubated for 24 hours with the indicated concentrations of [16] (A, C) or [20] (B, D). Each point represents mean±S.D. from 3~4 independent experiments.
- Figure 4.
Effect of compounds [16] and [20] on the formation of acid organelles. HSC-2 cells were incubated for 4 hours without (A) or with 87 (B) or 174 (C) μM [16], or 36.5 (D) or 73 (E) μM [20]. To induce autophagy, aliquots of the cells were cultured under starved condition in Hank's balanced salt solution (F). The cells were then stained with acridine orange and the formation of acid organelle was observed under confocal laser scanning microscope.
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