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Research ArticleExperimental Studies

Prognostic Impact of Protein Overexpression of the Proto-oncogene PIM-1 in Gastric Cancer

UTE WARNECKE-EBERZ, ELFRIEDE BOLLSCHWEILER, UTA DREBBER, RALF METZGER, STEPHAN E. BALDUS, ARNULF H. HÖLSCHER and STEFAN MÖNIG
Anticancer Research November 2009, 29 (11) 4451-4455;
UTE WARNECKE-EBERZ
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  • For correspondence: ute.warnecke-eberz{at}uk-koeln.de
ELFRIEDE BOLLSCHWEILER
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UTA DREBBER
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RALF METZGER
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STEPHAN E. BALDUS
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ARNULF H. HÖLSCHER
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STEFAN MÖNIG
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    Figure 1.

    Immunohistological localization of PIM-1 in gastric cancer. Strong positive brownish staining for PIM-1 in cytoplasm of tumor cells can be seen, while there is a lack of staining of stroma cells (×100).

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    Figure 2.

    Immunohistochemical detection of PIM-1 in gastric carcinoma and non-neoplastic cells. Expression: none <5%; low 5-35%; medium 35-65%; strong >65% PIM-1 positive cells.

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    Figure 3.

    Prognostic impact of PIM-1 overexpression in gastric glands compared to foveolae. Comparison of Kaplan-Meier curves including 117 gastric cancer patients. There was a significant difference between group 1: PIM-1 expression in gastric glands<expression in foveolae (upper curve) and group 2: PIM-1 expression in gastric glands≥expression in foveolae (lower curve). Overexpression of PIM-1 protein in gastric glands as compared to foveolae was significantly associated with poorer prognosis.

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Anticancer Research
Vol. 29, Issue 11
November 2009
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Prognostic Impact of Protein Overexpression of the Proto-oncogene PIM-1 in Gastric Cancer
UTE WARNECKE-EBERZ, ELFRIEDE BOLLSCHWEILER, UTA DREBBER, RALF METZGER, STEPHAN E. BALDUS, ARNULF H. HÖLSCHER, STEFAN MÖNIG
Anticancer Research Nov 2009, 29 (11) 4451-4455;

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Prognostic Impact of Protein Overexpression of the Proto-oncogene PIM-1 in Gastric Cancer
UTE WARNECKE-EBERZ, ELFRIEDE BOLLSCHWEILER, UTA DREBBER, RALF METZGER, STEPHAN E. BALDUS, ARNULF H. HÖLSCHER, STEFAN MÖNIG
Anticancer Research Nov 2009, 29 (11) 4451-4455;
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