Article Figures & Data
Figures
- Figure 1.
Effect of TBS-101 on proliferation and apoptosis in PC-3 cells. A, The number of viable cells after 24 h treatment. B, The proportion of apoptotic cells after 24 h treatment. Values are the mean±standard deviation (SD) of three parallel experiments.
- Figure 2.
Tolerance of healthy and tumor-bearing mice to TBS-101 treatment at various doses. A, Healthy mice were treated with 200 mg/kg of TBS-101 once every other day for 13 days and weighed periodically from Day 1 to Day 13. B, Tumor-bearing mice were treated with 1,000 mg/kg of TBS-101 once every other day for 19 days and weighed every other day. Values are the mean±standard deviation (SD).
- Figure 3.
Effect of TBS-101 on tumor growth in xenograft mice bearing PC-3 tumors of regular size. Mice bearing 170-400 mm3 tumors were treated with 80 mg/kg of TBS-101 or solvent alone (control) orally once every other day for 29 days and the tumor size was measured periodically. On Day 21, the control mice had to be sacrificed due to the tumor size exceeding the allowable tumor burden limit set by the animal facility. Values are the mean±standard deviation (SD).
- Figure 4.
Effect of TBS-101 on tumor growth in the xenograft animal model with large-sized tumors. When implanted PC-3 tumors had grown to 550-650 mm3 in size, the mice were treated with 80 mg/kg of TBS-101 or solvent alone (control) orally for 13 days and the tumor size was measured periodically. Values are the mean±standard deviation (SD).
- Figure 5.
Effect of TBS-101 on tumor growth in the xenograft animal model with very large sized tumors. When the PC-3 implanted tumors had grown to 700-800 mm3, the mice were treated with 80 mg/kg of TBS-101 or solvent alone (control) orally for 12 days and the tumor size was measured periodically. Values are the mean±standard deviation (SD).
- Figure 6.
Histology section of whole tumors from control and TBS-101 treated mice. Appearance and histology of two pairs (A and B) of H&E stained tumors (group 2 mice). Upper panel: section of the whole tumor (×20 magnification). Lower panel: selected tumor areas of the above tumors at higher magnification (×40). Panel a: control, vehicle alone; Panel b: from a mouse treated with TBS-101.
- Figure 7.
Effect of TBS-101 on the vascularization in tumors. A, Tumors from group 2 mice (×40 magnification) were stained with antibody against CD31. B, The number of CD31-positive pixels per microscopic field of regions of high vascular density at the center or the edge of the tumors. At least two sections per tumor and three views per section were determined. *Two-sided t-test p-value.
- Figure 8.
Effect of etoposide on tumor growth in the xenograft animal model. When the PC-3 implanted tumors had grown to 300-400 mm3 in size, the mice were treated with 20 mg/kg of etoposide or solvent alone (control) i.v. once every other day for 34 days. Tumor size was measured periodically. Values are the mean±standard deviation (SD).
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