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Research ArticleClinical Studies

Telomerase Activity in Head and Neck Cancer

ZUZANA KUNICKÁ, IGOR MUCHA and JIŘÍ FAJKUS
Anticancer Research September 2008, 28 (5B) 3125-3129;
ZUZANA KUNICKÁ
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IGOR MUCHA
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JIŘÍ FAJKUS
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  • For correspondence: fajkus@sci.muni.cz
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Abstract

Background: Telomerase activity is associated with many malignancies, including head and neck cancer. The use of telomerase activity as a diagnostic and prognostic marker of head and neck cancer development was examined and compared with standard histological analysis. Patients and Methods: Telomerase activity was determined using quantitative dual-colour real-time TRAP (telomeric repeat amplification protocol). In each of 58 patients, a sample of tumour tissue, adjacent mucosa and normal muscle was collected. Results: Telomerase activation was observed in 88% of tumour tissues and 34% of tumour-adjacent mucosa samples. No telomerase activity was detected in normal muscle tissues. Telomerase activity correlated with tumour grade, with an average of 4.6 telomerase units (T.U.) in well-differentiated, 8.3 T.U. in moderately-differentiated and 20 T.U. in poorly differentiated tumours. Relapse occurred in 13 patients and no telomerase activity was detected in 3 recurrent tumours. Conclusion: Telomerase activity may be used as an objective parameter inversely related to tumour differentiation. Prognosis in telomerase-negative tumours is worse than that of the telomerase-positive group.

  • Telomerase activity
  • head and neck cancer
  • real-time TRAP
  • prognosis
  • marker

Footnotes

  • Received June 3, 2008.
  • Revision received July 15, 2008.
  • Accepted August 8, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
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Telomerase Activity in Head and Neck Cancer
ZUZANA KUNICKÁ, IGOR MUCHA, JIŘÍ FAJKUS
Anticancer Research Sep 2008, 28 (5B) 3125-3129;

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Telomerase Activity in Head and Neck Cancer
ZUZANA KUNICKÁ, IGOR MUCHA, JIŘÍ FAJKUS
Anticancer Research Sep 2008, 28 (5B) 3125-3129;
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