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Research ArticleClinical Studies

Protective Effect of Cox-2 Allelic Variants on Risk of Colorectal Adenoma Development in African Americans

HASSAN ASHKTORAB, SHIRLEY TSANG, BRIAN LUKE, ZHONGHE SUN, LUCILE ADAM-CAMPBELL, JOHN KWAGYAN, RICHARD POIRIER, SHAHINA AKTER, AHMAD AKHGAR, DUANE SMOOT, DAVID J. MUNROE and IQBAL UNNISA ALI
Anticancer Research September 2008, 28 (5B) 3119-3123;
HASSAN ASHKTORAB
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SHIRLEY TSANG
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BRIAN LUKE
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ZHONGHE SUN
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LUCILE ADAM-CAMPBELL
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JOHN KWAGYAN
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RICHARD POIRIER
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SHAHINA AKTER
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AHMAD AKHGAR
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DUANE SMOOT
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DAVID J. MUNROE
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IQBAL UNNISA ALI
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  • For correspondence: iuali@cyber.net.pk
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Abstract

Background: Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development. Patients and Methods: We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used. Results: Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3′ flanking region downstream from the poly A signals (OR=0.39; CI=0.18-0.83; p=0.01) and the risk for colorectal adenoma development. Conclusion: The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.

  • Cox-2 polymorphisms
  • colorectal adenoma
  • African Americans

Footnotes

  • ↵* Both authors contributed equally to this work.

  • Received May 14, 2008.
  • Revision received July 25, 2008.
  • Accepted August 4, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
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September-October 2008
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Protective Effect of Cox-2 Allelic Variants on Risk of Colorectal Adenoma Development in African Americans
HASSAN ASHKTORAB, SHIRLEY TSANG, BRIAN LUKE, ZHONGHE SUN, LUCILE ADAM-CAMPBELL, JOHN KWAGYAN, RICHARD POIRIER, SHAHINA AKTER, AHMAD AKHGAR, DUANE SMOOT, DAVID J. MUNROE, IQBAL UNNISA ALI
Anticancer Research Sep 2008, 28 (5B) 3119-3123;

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Protective Effect of Cox-2 Allelic Variants on Risk of Colorectal Adenoma Development in African Americans
HASSAN ASHKTORAB, SHIRLEY TSANG, BRIAN LUKE, ZHONGHE SUN, LUCILE ADAM-CAMPBELL, JOHN KWAGYAN, RICHARD POIRIER, SHAHINA AKTER, AHMAD AKHGAR, DUANE SMOOT, DAVID J. MUNROE, IQBAL UNNISA ALI
Anticancer Research Sep 2008, 28 (5B) 3119-3123;
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