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Research ArticleClinical Studies

Fatal Thrombocytopenia after Oxaliplatin-based Chemotherapy

YU-YUN SHAO and RUEY-LONG HONG
Anticancer Research September 2008, 28 (5B) 3115-3117;
YU-YUN SHAO
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RUEY-LONG HONG
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  • For correspondence: rlhong@ntu.edu.tw
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Abstract

Oxaliplatin-related thrombocytopenia is considered rare and mostly self-limited. We present the first reported fatal case due to this complication. A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin. Consciousness changed on the next evening and deteriorated to deep coma within hours. Computed tomography revealed large intracranial hemorrhage with brain herniation. Hemogram showed severe thrombocytopenia, which was considered to be associated with oxaliplatin. The patient died six days later. The incidence of oxaliplatin-related thrombo-cytopenia may have been underestimated and its severity long neglected. Other hypersensitivity reactions may precede its onset. Early hemogram examination during hypersensitivity reaction to oxaliplatin may provide early diagnosis and the prevention of the possible fatal consequences.

  • Colorectal cancer
  • hypersensitivity reaction
  • intracranial hemorrhage
  • oxaliplatin
  • thrombocytopenia

Footnotes

  • Received May 6, 2008.
  • Revision received July 15, 2008.
  • Accepted August 4, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
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Fatal Thrombocytopenia after Oxaliplatin-based Chemotherapy
YU-YUN SHAO, RUEY-LONG HONG
Anticancer Research Sep 2008, 28 (5B) 3115-3117;

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Fatal Thrombocytopenia after Oxaliplatin-based Chemotherapy
YU-YUN SHAO, RUEY-LONG HONG
Anticancer Research Sep 2008, 28 (5B) 3115-3117;
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