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Research ArticleClinical Studies

Association Between Genetic Polymorphisms and Ovarian Cancer Risk

LAETITIA DELORT, NASSÉRA CHALABI, SAMIR SATIH, NADÈGE RABIAU, FABRICE KWIATKOWSKI, YVES-JEAN BIGNON and DOMINIQUE J BERNARD-GALLON
Anticancer Research September 2008, 28 (5B) 3079-3081;
LAETITIA DELORT
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NASSÉRA CHALABI
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SAMIR SATIH
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NADÈGE RABIAU
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FABRICE KWIATKOWSKI
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YVES-JEAN BIGNON
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  • For correspondence: Yves-Jean.BIGNON@cjp.fr
DOMINIQUE J BERNARD-GALLON
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Abstract

Background: The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. Patients and Methods: A case-control study was conducted to investigate the role of these polymorphisms in ovarian cancer risk. The participants were genotyped for eleven polymorphisms in seven genes involved in estrogen and xenobiotic metabolism (CYP1A1, CYP1B1, COMT, GSTP1, NAT2, estrogen receptor ESR, and progesterone receptor PGR). Results and Conclusion: The odds ratios for ovarian cancer risk were 2.02 (95% confidence interval [CI] = 1.14-3.56) in the NAT2 intermediate acetylators and 4.07 (95% CI = 1.30-12.70) in the slow acetylators. At least three cumulative high-risk genotypes increased ovarian cancer risk, but not significantly. More studies are needed in order to define genetic ovarian risk factors.

  • Ovarian cancer
  • polymorphisms
  • estrogen and xenobiotic metabolism

Footnotes

  • Received April 18, 2008.
  • Revision received June 10, 2008.
  • Accepted June 16, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
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Association Between Genetic Polymorphisms and Ovarian Cancer Risk
LAETITIA DELORT, NASSÉRA CHALABI, SAMIR SATIH, NADÈGE RABIAU, FABRICE KWIATKOWSKI, YVES-JEAN BIGNON, DOMINIQUE J BERNARD-GALLON
Anticancer Research Sep 2008, 28 (5B) 3079-3081;

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Association Between Genetic Polymorphisms and Ovarian Cancer Risk
LAETITIA DELORT, NASSÉRA CHALABI, SAMIR SATIH, NADÈGE RABIAU, FABRICE KWIATKOWSKI, YVES-JEAN BIGNON, DOMINIQUE J BERNARD-GALLON
Anticancer Research Sep 2008, 28 (5B) 3079-3081;
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