Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Evaluation of Fixed Dosing of New Anticancer Agents in Phase I Studies

DOMINIQUE LEVÊQUE
Anticancer Research September 2008, 28 (5B) 3075-3077;
DOMINIQUE LEVÊQUE
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dominique.leveque@chru-strasbourg.fr
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Aim: To assess the basis of dosage of investigational anticancer agents in adult phase I trials. Materials and Methods: All nonpediatric phase I trials presented at the meetings of the American Society of Clinical Oncology and of the American Society of Hematology in 2005 were reviewed. Data regarding the type of investigational agent, the route of administration and the basis of dosing (fixed, body surface area, body weight) were collected. Results: In all, 225 phase I studies were analyzed concerning 148 new anticancer agents. Among 225 studies, 91 (40.4%) used a fixed dose. Dosages were adjusted to body surface area and body weight in 44% (99/225) and 13.8% (31/225) of all trials, respectively. Regarding drugs given orally (n=40), the majority of the trials (62/77; 80%) used a fixed dose. By contrast, only 7.5% (9/120) of studies involving intravenous agents (n=82) were conducted with a fixed dose. Most of these trials (71.6%) used a dose adjusted to body surface area. Of the 73 trials involving conventional cytotoxics, 70 (96%) used body surface area dosing. On the other hand, 78.5% (62/79) of studies investigating targeted agents used a fixed dose. Monoclonal antibodies and antisense agents were mainly administered on a body weight basis (13/25 and 4/7 trials, respectively). Conclusion: A fixed dose was used in a minority of the adult phase I trials presented at the ASCO and ASH meetings in 2005.

  • Phase I
  • anticancer agents
  • fixed dose
  • body surface area
  • body weight

Footnotes

  • Received April 8, 2008.
  • Revision received June 26, 2008.
  • Accepted July 28, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Evaluation of Fixed Dosing of New Anticancer Agents in Phase I Studies
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
10 + 8 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Evaluation of Fixed Dosing of New Anticancer Agents in Phase I Studies
DOMINIQUE LEVÊQUE
Anticancer Research Sep 2008, 28 (5B) 3075-3077;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Evaluation of Fixed Dosing of New Anticancer Agents in Phase I Studies
DOMINIQUE LEVÊQUE
Anticancer Research Sep 2008, 28 (5B) 3075-3077;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Low-dose Apalutamide in Non-metastatic Castration-resistant Prostate Cancer: A Case Series
  • Bone Toxicity Case Report Combining Encorafenib, Cetuximab and WNT974 in a Phase I Trial
  • Assessment of Breakthrough Cancer Pain Among Female Patients With Cancer: Knowledge, Management and Characterization in the IOPS-MS Study
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire