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Research ArticleClinical Studies

Procalcitonin as a Useful Marker of Infection in Hemato-oncological Patients with Fever

MARIA T. SANDRI, RITA PASSERINI, MARIA E. LEON, FEDRO A. PECCATORI, LAURA ZORZINO, MICHELA SALVATICI, DANIELA RIGGIO, CRISTINA CASSATELLA, SAVERIO CINIERI and GIOVANNI MARTINELLI
Anticancer Research September 2008, 28 (5B) 3061-3065;
MARIA T. SANDRI
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  • For correspondence: maria.sandri@ieo.it
RITA PASSERINI
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MARIA E. LEON
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FEDRO A. PECCATORI
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LAURA ZORZINO
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MICHELA SALVATICI
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DANIELA RIGGIO
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CRISTINA CASSATELLA
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SAVERIO CINIERI
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GIOVANNI MARTINELLI
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Abstract

Background: The diagnostic utility of procalcitonin (PCT) and C-reactive protein (CRP) to discriminate between infective fever and fever due to inflammation was assessed in hemato-oncological patients treated with aggressive chemotherapy. Patients and Methods: Values of PCT and PCR measured on days -1, 0, 1, 3 and 5 of onset of fever were analyzed using longitudinal regression analysis. Of 236 febrile episodes in 166 patients, 39 were due to bacteremia, 62 to other infections and 135 were classified as fever of unknown origin. Results: PCT concentration increased early only in bacteremia and other infections (p<0.001), with the highest levels at day +1. No different trends were noted in patients with low WBC count (<1,000/μl). CRP increased with a similar trend in all the three groups. Conclusion: PCT determination may contribute significantly to the management of hemato-oncological patients who experience febrile episodes.

  • Procalcitonin
  • C-reactive protein
  • infection
  • leukopenia

Footnotes

  • ↵* Both these authors contributed equally to this paper.

  • Received April 8, 2008.
  • Revision received June 16, 2008.
  • Accepted June 24, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
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Procalcitonin as a Useful Marker of Infection in Hemato-oncological Patients with Fever
MARIA T. SANDRI, RITA PASSERINI, MARIA E. LEON, FEDRO A. PECCATORI, LAURA ZORZINO, MICHELA SALVATICI, DANIELA RIGGIO, CRISTINA CASSATELLA, SAVERIO CINIERI, GIOVANNI MARTINELLI
Anticancer Research Sep 2008, 28 (5B) 3061-3065;

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Procalcitonin as a Useful Marker of Infection in Hemato-oncological Patients with Fever
MARIA T. SANDRI, RITA PASSERINI, MARIA E. LEON, FEDRO A. PECCATORI, LAURA ZORZINO, MICHELA SALVATICI, DANIELA RIGGIO, CRISTINA CASSATELLA, SAVERIO CINIERI, GIOVANNI MARTINELLI
Anticancer Research Sep 2008, 28 (5B) 3061-3065;
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