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Research ArticleClinical Studies

Expression and Prognostic Significance of PDCD4 in Human Epithelial Ovarian Carcinoma

XIAOYAN WANG, ZENGTAO WEI, FEI GAO, XIA ZHANG, CHENGJUN ZHOU, FALIANG ZHU, QUN WANG, QI GAO, CHUNHONG MA, WENSHENG SUN, BEIHUA KONG and LINING ZHANG
Anticancer Research September 2008, 28 (5B) 2991-2996;
XIAOYAN WANG
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ZENGTAO WEI
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FEI GAO
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XIA ZHANG
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CHENGJUN ZHOU
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FALIANG ZHU
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QUN WANG
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QI GAO
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CHUNHONG MA
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WENSHENG SUN
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BEIHUA KONG
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  • For correspondence: immuno@sdu.edu.cn zhang_lining@hotmail.com kongbeihua@sdu.edu.cn
LINING ZHANG
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  • For correspondence: immuno@sdu.edu.cn zhang_lining@hotmail.com kongbeihua@sdu.edu.cn
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Abstract

Background: Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer. Materials and Methods: PDCD4 expression in 20 normal human ovaries and 69 serous ovarian tumors was examined by RT-PCR and immunohistochemistry. The relationships between PDCD4 expression, clinicopathological data and patient survival were evaluated. Results: PDCD4 expression was found to be lost or significantly lower in serous cystadenocarcinomas compared with that in normal ovaries and serous cystadenomas (p<0.05). The loss or reduction of PDCD4 expression in serous cystadenocarcinomas was significantly associated with higher pathological grade (p=0.0118) and poorer disease-specific survival of patients (p=0.0011). Multivariant Cox regression analysis revealed that PDCD4 expression was an independent prognostic factor for serous cystadenocarcinoma. Conclusion: Lost or reduced PDCD4 expression is associated with the progression of serous cystadenocarcinomas and may serve as an important prognostic marker.

  • Programmed cell death 4 (PDCD4)
  • expression
  • ovarian cancer
  • prognosis

Footnotes

  • ↵* Both authors contributed equally to this work.

  • Received May 2, 2008.
  • Revision received June 18, 2008.
  • Accepted June 23, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
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Vol. 28, Issue 5B
September-October 2008
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Expression and Prognostic Significance of PDCD4 in Human Epithelial Ovarian Carcinoma
XIAOYAN WANG, ZENGTAO WEI, FEI GAO, XIA ZHANG, CHENGJUN ZHOU, FALIANG ZHU, QUN WANG, QI GAO, CHUNHONG MA, WENSHENG SUN, BEIHUA KONG, LINING ZHANG
Anticancer Research Sep 2008, 28 (5B) 2991-2996;

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Expression and Prognostic Significance of PDCD4 in Human Epithelial Ovarian Carcinoma
XIAOYAN WANG, ZENGTAO WEI, FEI GAO, XIA ZHANG, CHENGJUN ZHOU, FALIANG ZHU, QUN WANG, QI GAO, CHUNHONG MA, WENSHENG SUN, BEIHUA KONG, LINING ZHANG
Anticancer Research Sep 2008, 28 (5B) 2991-2996;
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