Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

TUNEL as a Tumor Marker of Tongue Cancer

OFER BEN-IZHAK, ZVI LASTER, SHARON AKRISH, GOLAN COHEN and RAFAEL M. NAGLER
Anticancer Research September 2008, 28 (5B) 2981-2986;
OFER BEN-IZHAK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ZVI LASTER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SHARON AKRISH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GOLAN COHEN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
RAFAEL M. NAGLER
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: nagler@tx.technion.tc.il
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Squamous cell carcinoma (SCC) of the tongue has an increasing incidence, a high morbidity rate and a 50% 5-year mortality rate. We analyzed the rate of apoptosis using TDT-mediated dUTP-biotin nick end-labeling (TUNEL), p53 and heparanase in 73 patients with tongue cancer by immonohistochemistry, and tested data for correlation with survival, tumor size, grade and metastasis. TUNEL staining was strong in 54% of the tumors; the remainder lacked staining, as did all healthy control tissues. Significant correlations were found between TUNEL staining level and p53 expression rates (p=0.016) and between TUNEL and heparanase (p=0.039). Moreover, while the cumulative 5-year survival probability for tumors not stained for TUNEL and p53 was 63%, but dropped to 34% with TUNEL staining; for lack of TUNEL and heparanase (=0), 5-year survival rate was 50%, while staining presence (>0) reduced survival to 34% . TUNEL joins other biomarkers in indicating prognosis of understanding pathogenesis of tongue cancer.

  • TUNEL
  • p53
  • heparanase
  • tumor marker
  • tongue cancer
  • oral cancer

Footnotes

  • Received February 26, 2008.
  • Revision received July 7, 2008.
  • Accepted July 8, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
PreviousNext
Back to top

In this issue

Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
TUNEL as a Tumor Marker of Tongue Cancer
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
16 + 3 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
TUNEL as a Tumor Marker of Tongue Cancer
OFER BEN-IZHAK, ZVI LASTER, SHARON AKRISH, GOLAN COHEN, RAFAEL M. NAGLER
Anticancer Research Sep 2008, 28 (5B) 2981-2986;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
TUNEL as a Tumor Marker of Tongue Cancer
OFER BEN-IZHAK, ZVI LASTER, SHARON AKRISH, GOLAN COHEN, RAFAEL M. NAGLER
Anticancer Research Sep 2008, 28 (5B) 2981-2986;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Bone Toxicity Case Report Combining Encorafenib, Cetuximab and WNT974 in a Phase I Trial
  • Assessment of Breakthrough Cancer Pain Among Female Patients With Cancer: Knowledge, Management and Characterization in the IOPS-MS Study
  • Low-dose Apalutamide in Non-metastatic Castration-resistant Prostate Cancer: A Case Series
Show more Clinical Studies

Similar Articles

Anticancer Research

© 2025 Anticancer Research

Powered by HighWire