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Research ArticleClinical Studies

Positive Correlation between Cyclooxygenase 2 and the Expression of ABC Transporters in Non-small Cell Lung Cancer

PAWEŁ SUROWIAK, KONRAD PAWEŁCZYK, ADAM MACIEJCZYK, MAREK PUDEŁKO, JERZY KOŁODZIEJ, MACIEJ ZABEL, DAWID MURAWA, MARCIN DRAG, TSERENCHUNT GANSUKH, MANFRED DIETEL and HERMANN LAGE
Anticancer Research September 2008, 28 (5B) 2967-2974;
PAWEŁ SUROWIAK
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KONRAD PAWEŁCZYK
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ADAM MACIEJCZYK
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MAREK PUDEŁKO
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JERZY KOŁODZIEJ
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MACIEJ ZABEL
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DAWID MURAWA
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MARCIN DRAG
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TSERENCHUNT GANSUKH
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MANFRED DIETEL
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HERMANN LAGE
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  • For correspondence: hermann.lage@charite.de
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Abstract

Background: The primary method of treatment of non-small cell lung cancer (NSCLC) in stage IIIB and IV is chemotherapy. Previous data suggested a correlation between cyclooxygenase-2 (COX-2) expression and the multidrug-resistant phenotype of cancer cells. Materials and Methods: In this prospective study, 32 patients with NSCLC in stage IIIB and IV from 1,078 patients were included. The expression of COX-2 as well as the expression of the ABC transporters MDR1/P-glycoprotein (MDR1/P-gp), BCRP and MRP1 were detected immunohistochemically. Results: Univariate and multivariate analyses demonstrated no prognostic or predictive significance of these proteins. It was merely demonstrated that complete or partial response are favourable factors for prediction of longer progression-free survival time. However, a strong positive correlation between the expression of COX-2, MDR1/P-gp and BCRP was found in NSCLC. Conclusion: These data suggest no clinical impact for the expression of MDR1/P-gp, MRP1, BCRP or COX-2 in NSCLC, but a putative coregulation of COX-2 and MDR1/P-gp and BCRP in NSCLC.

  • Non-small cell lung cancer
  • COX-2
  • ABC transporters
  • chemotherapy

Footnotes

  • Received March 18, 2008.
  • Revision received June 26, 2008.
  • Accepted July 4, 2008.
  • Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5B)
Anticancer Research
Vol. 28, Issue 5B
September-October 2008
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Positive Correlation between Cyclooxygenase 2 and the Expression of ABC Transporters in Non-small Cell Lung Cancer
PAWEŁ SUROWIAK, KONRAD PAWEŁCZYK, ADAM MACIEJCZYK, MAREK PUDEŁKO, JERZY KOŁODZIEJ, MACIEJ ZABEL, DAWID MURAWA, MARCIN DRAG, TSERENCHUNT GANSUKH, MANFRED DIETEL, HERMANN LAGE
Anticancer Research Sep 2008, 28 (5B) 2967-2974;

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Positive Correlation between Cyclooxygenase 2 and the Expression of ABC Transporters in Non-small Cell Lung Cancer
PAWEŁ SUROWIAK, KONRAD PAWEŁCZYK, ADAM MACIEJCZYK, MAREK PUDEŁKO, JERZY KOŁODZIEJ, MACIEJ ZABEL, DAWID MURAWA, MARCIN DRAG, TSERENCHUNT GANSUKH, MANFRED DIETEL, HERMANN LAGE
Anticancer Research Sep 2008, 28 (5B) 2967-2974;
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