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Research ArticleExperimental Studies

Soy Extract Is More Potent than Genistein on Tumor Growth Inhibition

HYEON-A KIM, KYU-SHIK JEONG and YOO KYEONG KIM
Anticancer Research September 2008, 28 (5A) 2837-2841;
HYEON-A KIM
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KYU-SHIK JEONG
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YOO KYEONG KIM
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  • For correspondence: yookim@knu.ac.kr
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Abstract

Soybean and soy products have received much attention for their potential heath benefits. Recently it has been reported that the bioactivity of soy products is influenced by the degree of soy processing. This study was conducted to evaluate and compare the influence of diets containing genistein and soy extract on the growth of the estrogen-independent human breast cancer cells, MDA-MB-231, implanted into female Balb/c mice. Four-week-old female athymic nude mice (Balb/c) were acclimatized to an AIN-93G control diet for one week prior to initiating the experimental diets. The animals were placed into three treatment groups, each of which was provided with containing DMSO, genistein (750 μg/g AIN-93G diet) or 0.6% soy extract (containing genistein at 750 μg/g AIN-93G diet) for three weeks from one week prior to the injection of MDA-MB-231 cells (1×106/site) and subsequently fed on the AIN-93G control diet until sacrifice. The tumor volumes increased steeply in the control group and the genistein-treated group. However, tumor growth was significantly reduced in the soy extract-treated group compared to the control and genistein-treated groups. Immunohistochemistry of proliferating cell nuclear antigen (PCNA) also revealed that the soy extract treatment effectively reduced cell proliferation of the implanted tumors. In conclusion, soy extract is more potent than genistein in the inhibition of tumor growth, presumably resulting from the synergistic effect of the various bioactive components in the soy extract.

  • Genistein
  • soy extract
  • MDA-MB-231 cell
  • nude mice
  • tumor growth
  • Received March 26, 2008.
  • Revision received June 10, 2008.
  • Accepted July 7, 2008.
  • Copyright© 2008 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Anticancer Research: 28 (5A)
Anticancer Research
Vol. 28, Issue 5A
September-October 2008
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Soy Extract Is More Potent than Genistein on Tumor Growth Inhibition
HYEON-A KIM, KYU-SHIK JEONG, YOO KYEONG KIM
Anticancer Research Sep 2008, 28 (5A) 2837-2841;

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Soy Extract Is More Potent than Genistein on Tumor Growth Inhibition
HYEON-A KIM, KYU-SHIK JEONG, YOO KYEONG KIM
Anticancer Research Sep 2008, 28 (5A) 2837-2841;
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